iolT
168
major transporter for inositol
locus
BSU_06230
Molecular weight
51.47 kDa
pI
9.57
function
myo-inositol uptake
product
major transporter for inositol
essential
no
synonyms
iolT, ydjK
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2814 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
676,442 677,863
The protein
Catalyzed reaction/ biological activity
transport of myo-inositol [Pubmed|20530884]
Protein family
[wiki|major facilitator superfamily] (according to UniProt)
[wiki|Sugar transporter (TC 2.A.1.1) family] (according to UniProt)
Structure
[PDB|4LDS] (glucose transporter from Staphylococcus epidermidis, 36% identity) [pubmed|24127585]
[AF|O34718]
Paralogous protein(s)
[protein|4A77316AA94F9C11DB70AB76711AACBD28098AA1|IolT], [protein|770D9A5BEEEABE9C3FC772E74001329206ECFAB3|araE], [protein|7CE5A42042E5D52768735E795DB805530691D8A6|ywtG], [protein|8B0701B5694ABA8142476CB896E590FE1981D7DB|yfiG], [protein|A84AC4E40E7C722E27AE9C24ACECFEABD51B57BE|yncC], [protein|0757FAEB38AA1C599C5067794AF83A4BA5912DC9|csbC]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|4A77316AA94F9C11DB70AB76711AACBD28098AA1|iolT]
description
[pubmed|22383849]
regulation
induced in the presence of inositol ([protein|5F4ABBC8ECAD6F6C10EC39B2B0F0BC73F11522CE|iolR]) [Pubmed|11807058]
regulatory mechanism
[protein|5F4ABBC8ECAD6F6C10EC39B2B0F0BC73F11522CE|iolR]: repression, [pubmed|11807058], in [regulon|protein:5F4ABBC8ECAD6F6C10EC39B2B0F0BC73F11522CE|iolR regulon]
Biological materials
Mutant
MGNA-C218 (ydjK::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2216 NBRP B. subtilis, Japan]
BKE06230 ([gene|4A77316AA94F9C11DB70AB76711AACBD28098AA1|iolT]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE06230 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATACTGTTTCCCCCAGTCT, downstream forward: _UP4_TAATTTAAAAAAGAATCCGC
BKK06230 ([gene|4A77316AA94F9C11DB70AB76711AACBD28098AA1|iolT]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK06230 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATACTGTTTCCCCCAGTCT, downstream forward: _UP4_TAATTTAAAAAAGAATCCGC
References
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Time of last update: 2024-12-22 10:56:05
Author of last update: Melvin.boenninger