uppS

uppS
168

undecaprenyl pyrophosphate synthetase, provides the precursor for the carrier lipid, undecaprenyl phosphate (C55-P), which is required for cell wall synthesis

locus
BSU_16530
Molecular weight
29.63 kDa
pI
5.41
Protein length
Gene length
function
cell wall biosynthesis
product
undecaprenyl pyrophosphate synthetase
essential
yes
ec
2.5.1.31
synonyms
uppS, yluA

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0020 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,721,214  1,721,996
Phenotypes of a mutant
essential [Pubmed|22904278]
''uppS'' is dispensable in wall-less L-forms [Pubmed|24704074]
the ''[wiki|uppS86]'' (C257T) mutation provides resistance to rare earth metals such as scandium and to bacitracin [Pubmed|22904278]
inactivation suppresses the essentiality of [gene|6ED386D49F973C1F6B1076974F54275DD583C9D3|mbl] [pubmed|39185233]
The protein
Catalyzed reaction/ biological activity
catalyzes eight consecutive condensation reactions of isopentenyl pyrophosphate (IPP) with farnesyl pyrophosphate (FPP) to form undecaprenyl pyrophosphate
Protein family
UPP synthetase family (single member, according to UniProt)
Structure
[PDB|1X09] (the protein from ''E. coli'', 49% identity, 77% similarity) [Pubmed|15788389]
[AF|O31751]
Expression and Regulation
Operons
genes
[gene|4A637EB9B400D30E5C6246D1E0EB5E6A30F38A16|uppS]-[gene|7E7F6BBA03C443A5AFA05A6D9352FEF1212A5AF6|cdsA]-[gene|58CDF08A8F05C0BC25EB6E400316F85FD0F307E5|ispC]-[gene|CB50289535EA537F63BADD459BD11AA7759A6658|rasP]-[gene|848570563D3C92A8E1E6AB4DA530388D8AE94E75|proS]-[gene|FB97DF0C147FB29944F60214CB9BC1803861DAA0|polC]
description
[Pubmed|22383849]
Open in new tab

[gene|4A637EB9B400D30E5C6246D1E0EB5E6A30F38A16|uppS]→[gene|FB97DF0C147FB29944F60214CB9BC1803861DAA0|polC]

2024-09-05 23:02:44

Jstuelk

122

c6a20b58d42a343484ae9ff8f9312018bf0f82f2

3AF78B34597AE93B1AF63769A0A2561D91069003

Biological materials
Mutant
MGNA-B080 (yluA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1079 NBRP B. subtilis, Japan]
References
22904278,23796923,15788389,23840410,24704074,27578312,34473495,36515540,36815589,39185233

4A637EB9B400D30E5C6246D1E0EB5E6A30F38A16

Page visits: 6380

Time of last update: 2024-10-06 12:47:36

Author of last update: Jstuelk