uppS
168
undecaprenyl pyrophosphate synthetase, provides the precursor for the carrier lipid, undecaprenyl phosphate (C55-P), which is required for cell wall synthesis
locus
BSU_16530
Molecular weight
29.63 kDa
pI
5.41
function
cell wall biosynthesis
product
undecaprenyl pyrophosphate synthetase
essential
yes
ec
2.5.1.31
synonyms
uppS, yluA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0020 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,721,214 1,721,996
Phenotypes of a mutant
essential [Pubmed|22904278]
''uppS'' is dispensable in wall-less L-forms [Pubmed|24704074]
the ''[wiki|uppS86]'' (C257T) mutation provides resistance to rare earth metals such as scandium and to bacitracin [Pubmed|22904278]
inactivation suppresses the essentiality of [gene|6ED386D49F973C1F6B1076974F54275DD583C9D3|mbl] [pubmed|39185233]
The protein
Catalyzed reaction/ biological activity
catalyzes eight consecutive condensation reactions of isopentenyl pyrophosphate (IPP) with farnesyl pyrophosphate (FPP) to form undecaprenyl pyrophosphate
Protein family
UPP synthetase family (single member, according to UniProt)
Structure
[PDB|1X09] (the protein from ''E. coli'', 49% identity, 77% similarity) [Pubmed|15788389]
[AF|O31751]
Expression and Regulation
Operons
genes
[gene|4A637EB9B400D30E5C6246D1E0EB5E6A30F38A16|uppS]-[gene|7E7F6BBA03C443A5AFA05A6D9352FEF1212A5AF6|cdsA]-[gene|58CDF08A8F05C0BC25EB6E400316F85FD0F307E5|ispC]-[gene|CB50289535EA537F63BADD459BD11AA7759A6658|rasP]-[gene|848570563D3C92A8E1E6AB4DA530388D8AE94E75|proS]-[gene|FB97DF0C147FB29944F60214CB9BC1803861DAA0|polC]
description
[Pubmed|22383849]
Biological materials
Mutant
MGNA-B080 (yluA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1079 NBRP B. subtilis, Japan]
References
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Time of last update: 2024-12-21 15:35:12
Author of last update: Jstuelk