cotG

cotG
168

outer spore coat protein

locus
BSU_36070
Molecular weight
23.81 kDa
pI
10.67
Protein length
Gene length
function
control of spore permeability, resistance of the spore
product
spore coat protein
essential
no
synonyms
cotG

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms

This gene is a member of the following regulons

Gene
Coordinates
3,717,238  3,717,825
The protein
Catalyzed reaction/ biological activity
required for the maturation of [protein|2A0B2CA7C982C03C1AFBDB3540A918EE937B06CB|cotB] [Pubmed|26953338]
Structure
[AF|P39801]
Modification
phosphorylated on Ser-15, Ser-39, and Thr-147 by [protein|D53067098F693669F61E5CCF6C06664580C40C79|cotH], phosphorylation does not take place at increased temperature [Pubmed|35254711,27185916,25115591]
[wiki|Localization]
outer spore coat, localization depends on [protein|825AD8D4315A85CD384F9AF6AD894E38E57C88F7|cotE]  [Pubmed|22171814]
assembly around the forming spore depends on [protein|D53067098F693669F61E5CCF6C06664580C40C79|cotH]-mediated phosphorylation [pubmed|35254711]
accumulation In the mother cell (non-phosphorylated [protein|49BAFE3E69F1F91AEF4154F55B44639DD3CE4A71|cotG]) [pubmed|35254711]
Expression and Regulation
Operons
genes
[gene|49BAFE3E69F1F91AEF4154F55B44639DD3CE4A71|cotG]
description
[Pubmed|7814326]
regulation
expressed late during sporulation in the mother cell ([protein|search|SigE], [protein|search|SigK], [protein|search|GerE]) [Pubmed|15383836,15699190,7814326]
regulatory mechanism
[protein|19228BAD44E6DA3DE908DC390FDF628C18D94E65|gerE]: activation, [Pubmed|7814326], in [regulon|protein:19228BAD44E6DA3DE908DC390FDF628C18D94E65|gerE regulon]
[protein|0D7F5504590512E1598B94DC1734BF8FF67ED994|gerR]: activation, [Pubmed|15621419], in [regulon|protein:0D7F5504590512E1598B94DC1734BF8FF67ED994|gerR regulon]
sigma factors
[protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]: sigma factor, [Pubmed|15383836], in [regulon|protein:3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE regulon]
[protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK]: sigma factor, [Pubmed|15699190,7814326], in [regulon|protein:24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK regulon]
additional information
the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed]
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[gene|49BAFE3E69F1F91AEF4154F55B44639DD3CE4A71|cotG]

2024-12-26 12:34:21

ghost

82

792553c0731f2fb80ff7d175412af401d53b94ea

17085D1BC6E8C6F57E34876C6606BF13F70EC593

Biological materials
Mutant
BKE36070 ([gene|49BAFE3E69F1F91AEF4154F55B44639DD3CE4A71|cotG]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE36070 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAATTTGAAATCCTCCTTTT,  downstream forward: _UP4_TAATCTAAGTTTTCATTGTT
BKK36070 ([gene|49BAFE3E69F1F91AEF4154F55B44639DD3CE4A71|cotG]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK36070 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAATTTGAAATCCTCCTTTT,  downstream forward: _UP4_TAATCTAAGTTTTCATTGTT
References
12884008,7814326,9573176,14762006,15699190,15621419,22171814,21984783,15383836,25115591,26953338,27185916,30088242,31713316,32592201,35254711,36354330,36815589

49BAFE3E69F1F91AEF4154F55B44639DD3CE4A71

Page visits: 6362

Time of last update: 2024-12-30 06:58:05

Author of last update: Jstuelk