ykgB

ykgB
168

6-phosphogluconolactonase, general stress protein

locus
BSU_13010
Molecular weight
38.26 kDa
pI
5.15
Protein length
349 aaSequenceBlast
Gene length
1050 bpSequenceBlast
function
pentose phosphate pathway
product
6-phosphogluconolactonase
essential
no
ec
3.1.1.31
synonyms
ykgB, pgl
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2706 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,369,876  1,370,925
The protein
Catalyzed reaction/ biological activity
6-phosphogluconolactone - 6-phosphogluconate (pentose phosphate pathway) [Pubmed|22960854]
Protein family
cycloisomerase 2 family (single member, according to UniProt)
Structure
[PDB|3HFQ] (from ''Lactobacillus plantarum'', 42% identity)
[AF|O34499]
Expression and Regulation
Operons
genes
[gene|E8ECEFF86ABD1A2BE439F3CAD5A7C5BB58C4BF8E|ykgA]-[gene|491B5E27EF3190D307EC43C3BB12490728E39333|ykgB]
description
[Pubmed|10482513]
regulation
induced by stress ([protein|search|SigB]) [Pubmed|10482513]
sigma factors
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]: sigma factor, [Pubmed|10482513], in [regulon|protein:580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB regulon]
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[gene|E8ECEFF86ABD1A2BE439F3CAD5A7C5BB58C4BF8E|ykgA]→[gene|491B5E27EF3190D307EC43C3BB12490728E39333|ykgB]

2024-08-08 21:28:50

ghost

47

a39b40eeb2284f606e51d9812a8414feff4018bd

FEDFF840442A24C5B146C9952E5EF42339E13918

Biological materials
Mutant
MGNA-A754 (ykgB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/754 NBRP B. subtilis, Japan]
BKE13010 ([gene|491B5E27EF3190D307EC43C3BB12490728E39333|ykgB]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE13010 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGCGATTTCCCCCTTAAA,  downstream forward: _UP4_TAAACAAATGGAGTGGCTCT
BKK13010 ([gene|491B5E27EF3190D307EC43C3BB12490728E39333|ykgB]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK13010 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGCGATTTCCCCCTTAAA,  downstream forward: _UP4_TAAACAAATGGAGTGGCTCT
FLAG-tag construct
GP1402 (spc, based on [wiki|pGP1331]), available in [wiki|Jörg Stülke]'s lab
References
10482513,15576773,22960854

491B5E27EF3190D307EC43C3BB12490728E39333

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Time of last update: 2024-09-16 12:53:45

Author of last update: Robert.warneke