fliS
168
chaperone for the export of [protein|E0BB77C8F1220E931D16A1FA6B75AE8907C76FDB|flagellin]
locus
BSU_35330
Molecular weight
14.99 kDa
pI
5.23
function
[category|SW.4.1.1|Motility and chemotaxis]
product
chaperone for [protein|E0BB77C8F1220E931D16A1FA6B75AE8907C76FDB|flagellin] export
essential
no
synonyms
fliS
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1516 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,632,488 3,632,889
Phenotypes of a mutant
defective in [category|SW.4.1.4|Swarming] motility [pubmed|35638827]
The protein
Catalyzed reaction/ biological activity
prevents premature assembly of [protein|E0BB77C8F1220E931D16A1FA6B75AE8907C76FDB|hag] [Pubmed|26490009]
Protein family
FliS family (single member, according to UniProt)
Structure
[PDB|1VH6] [Pubmed|16021622]
[PDB|6GOW] (complex with flagellin) [Pubmed|30068950]
[AF|P39739]
[wiki|Localization]
cytoplasm (according to UniProt)
Expression and Regulation
Operons
genes
[gene|4DBF4635B5C5A7541E8F97440D139DAA02547B99|yvyC]-[gene|C6012DEA301DF5B2DDD7E673A736BD3E5163F209|fliD]-[gene|4882FAD988FEDD0E72E4CAFB10C8DE61DDAC23B0|fliS]-[gene|4DE156D248FAF7DE3ED9AC35F006B5319A3C1BDA|fliT]-[gene|A6E7212D159F076F5D26F9C02F340B40C3667623|smiA]-[gene|06FEA5F205B40DD5CF8D9F1328E940D4543F4741|S1350]-[gene|37B8B671B84266A7D65B90A9077A0DFF458D1851|hpf]
description
[pubmed|22383849]
sigma factors
[protein|7024E4162A6D827069F882FDEACA696EBC05DD40|sigD]: sigma factor, [Pubmed|26577401], in [regulon|protein:7024E4162A6D827069F882FDEACA696EBC05DD40|sigD regulon]
genes
[gene|4DBF4635B5C5A7541E8F97440D139DAA02547B99|yvyC]-[gene|C6012DEA301DF5B2DDD7E673A736BD3E5163F209|fliD]-[gene|4882FAD988FEDD0E72E4CAFB10C8DE61DDAC23B0|fliS]-[gene|4DE156D248FAF7DE3ED9AC35F006B5319A3C1BDA|fliT]
description
[Pubmed|8195064]
sigma factors
[protein|7024E4162A6D827069F882FDEACA696EBC05DD40|sigD]: sigma factor, [Pubmed|8195064], in [regulon|protein:7024E4162A6D827069F882FDEACA696EBC05DD40|sigD regulon]
Biological materials
Mutant
BKE35330 ([gene|4882FAD988FEDD0E72E4CAFB10C8DE61DDAC23B0|fliS]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE35330 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTGTCATCCTCCAAATT, downstream forward: _UP4_CGGCACGGATCAGGCGGGAT
BKK35330 ([gene|4882FAD988FEDD0E72E4CAFB10C8DE61DDAC23B0|fliS]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK35330 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTGTCATCCTCCAAATT, downstream forward: _UP4_CGGCACGGATCAGGCGGGAT
References
Reviews
Original Publications
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Time of last update: 2024-10-09 04:08:50
Author of last update: Jstuelk