fpbP
168
petrobactin (3.4-catecholate siderophore) [wiki|ABC transporter] ([metabolite|ATP]-binding protein)
locus
BSU_03820
Molecular weight
28.33 kDa
pI
5.09
function
acquisition of iron
product
petrobactin [wiki|ABC transporter] ([metabolite|ATP]-binding protein)
essential
no
synonyms
fpbP, yclP
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG4604 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
434,256 435,014
The protein
Catalyzed reaction/ biological activity
uptake of the siderophore petrobactin [Pubmed|19955416]
Fe(III)-siderophore + ATP + H2O --> Fe(III)-siderophore + ADP + H+ + phosphate (according to UniProt)
Protein family
[wiki|ABC transporter superfamily] (according to UniProt)
[wiki|Domains]
[wiki|ABC transporter domain] (aa 2-236) (according to UniProt)
Structure
[PDB|4YMS] (amino acid transporter from Caldanaerobacter subterraneus, 31% identity) [pubmed|25848002]
[AF|P94420]
Paralogous protein(s)
[protein|5C52DB31F378E49AABE5D937DD901A68F3810477|yusV], [protein|E70BE74D5AB4B06CDFF902E58A0B9EBF477E21EC|fhuC], [protein|E76640F895261DA34AD2342B54B43D11857AEA9A|fecF]
[wiki|Localization]
associated to the membrane (via [protein|552D4C42DCEA4625000160D2625711C61AB11661|fpbN]-[protein|EC63B5CDFDB4DF3A967ECEC40F2C44849311148B|fpbO]) [Pubmed|10092453]
Expression and Regulation
Operons
genes
[gene|552D4C42DCEA4625000160D2625711C61AB11661|fpbN]-[gene|EC63B5CDFDB4DF3A967ECEC40F2C44849311148B|fpbO]-[gene|473628F86C18FE9957841F3C8B45242C90CB341D|fpbP]-[gene|C1D6D188E5BD039F32427B2A58BBFC0CC173A476|fpbQ]
description
[Pubmed|19955416]
regulation
immediately induced upon iron starvation (first wave to allow iron uptake) ([protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur]) [Pubmed|29133393,12354229]
regulatory mechanism
[protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur]: repression, [pubmed|12354229], in [regulon|protein:F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur regulon]
Biological materials
Mutant
MGNA-C011 (yclP::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2009 NBRP B. subtilis, Japan]
BKE03820 ([gene|473628F86C18FE9957841F3C8B45242C90CB341D|fpbP]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE03820 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTGTTTGCTTACATTTCTGA, downstream forward: _UP4_TAATATATAGAAGAGGTGAG
BKK03820 ([gene|473628F86C18FE9957841F3C8B45242C90CB341D|fpbP]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK03820 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTGTTTGCTTACATTTCTGA, downstream forward: _UP4_TAATATATAGAAGAGGTGAG
References
Page visits: 5116
Time of last update: 2024-12-22 08:18:52
Author of last update: Jstuelk