rapD
168
response regulator aspartate phosphatase, controls [protein|search|ComA ]activity
locus
BSU_36380
Molecular weight
41.98 kDa
pI
7.69
function
control of [protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|comA]-dependent gene expression
product
response regulator aspartate phosphatase
essential
no
synonyms
rapD, ywpA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms
This gene is a member of the following regulons
Gene
Coordinates
3,744,349 3,745,413
The protein
Catalyzed reaction/ biological activity
control of [protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|comA]-dependent gene expression [Pubmed|17227471]
Protein family
[wiki|RAP family] (according to UniProt)
[wiki|Domains]
six [wiki|TPR repeat|tetratrichopeptide repeats] (according to UniProt)
Structure
[PDB|4I9E] ([protein|1F860F4E66A3D503D5A97F17D4AB0504BEFE7F9D|rapF], 26% identity) [pubmed|23526880]
[AF|P94583]
Expression and Regulation
Operons
genes
[gene|4670F7C4CB9084A5BA478CAE238FA0F8C39F3A7E|rapD]
description
[Pubmed|9636707]
regulation
repressed by [protein|972401B6AF56EC67FE6F1C3FEA9E2A9FC77C7672|rghR] [Pubmed|17227471]
expression
expression is heterogeneous [pubmed|35171018]
regulatory mechanism
[protein|972401B6AF56EC67FE6F1C3FEA9E2A9FC77C7672|rghR]: repression, [Pubmed|17227471], in [regulon|protein:972401B6AF56EC67FE6F1C3FEA9E2A9FC77C7672|rghR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|9636707], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM]: sigma factor, [Pubmed|18179421], in [regulon|protein:081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM regulon]
[protein|E77364F274A520FCCA9F5C9504E317B047BA29E6|sigX]: sigma factor, [Pubmed|9636707], in [regulon|protein:E77364F274A520FCCA9F5C9504E317B047BA29E6|sigX regulon]
Biological materials
Mutant
MGNA-A079 (rapD::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/79 NBRP B. subtilis, Japan]
BKE36380 ([gene|4670F7C4CB9084A5BA478CAE238FA0F8C39F3A7E|rapD]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE36380 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTTCCTACCTCTTTGCT, downstream forward: _UP4_TGATTGAAAAACGCCCATTT
BKK36380 ([gene|4670F7C4CB9084A5BA478CAE238FA0F8C39F3A7E|rapD]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK36380 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTTCCTACCTCTTTGCT, downstream forward: _UP4_TGATTGAAAAACGCCCATTT
References
Reviews
Original Publications
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Time of last update: 2024-12-21 15:06:55
Author of last update: Jstuelk