psdA
168
[wiki|ABC transporter] ([metabolite|ATP]-binding protein) for the export of lipid II-binding lantibiotics, such as nisin and gallidermin
locus
BSU_34700
Molecular weight
28.89 kDa
pI
6.34
function
export of toxic peptides
product
[wiki|ABC transporter] ([metabolite|ATP]-binding protein)
essential
no
synonyms
psdA, yvcR
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1136 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,565,496 3,566,275
The protein
Protein family
[wiki|ABC transporter superfamily] (according to UniProt)
[wiki|Domains]
[wiki|ABC transporter domain] (aa 4-248) (according to UniProt)
Structure
[PDB|1L2T] (MJ0796 from Methanocaldococcus jannaschii, 44% identity) [Pubmed|12150914]
[AF|O06980]
Paralogous protein(s)
[protein|8B4267532B9788AEB5EF39E2695C1FDA494C7055|yxdL], [protein|8BF7EB539B53D75BD30BD30ABF27106D6A0B030B|ftsE], [protein|8E0DE8FE7E9C12495C4DCADA74D838FED088867D|bceA], [protein|FE3A01BEA974C5E32C68DC600C800E5EF101B34F|yknY], [protein|0F8048267EC038D8CF673317D969BA27735473A7|yvrO]
[wiki|Localization]
membrane associated (via [protein|AC7F08DC1DF7DD2F9AFF84041D357B286B1244AC|psdB]) [Pubmed|10092453]
Expression and Regulation
Operons
genes
[gene|985E7F25C809AA5DF372101E64960DF704EED53F|psdR]-[gene|A9525886E911164BDFF0A55DA9F5FDD1C1B7A3B6|psdS]-[gene|464DD1855E6B3195EE242637612A16C73FF32FC0|psdA]-[gene|AC7F08DC1DF7DD2F9AFF84041D357B286B1244AC|psdB]
description
[Pubmed|21078927]
regulation
''[protein|search|psdA]'': induced by nisin, gallidermin ([protein|search|PsdR]) [Pubmed|21078927]
regulatory mechanism
[protein|985E7F25C809AA5DF372101E64960DF704EED53F|psdR]: activation, [Pubmed|21078927], in [regulon|protein:985E7F25C809AA5DF372101E64960DF704EED53F|psdR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|21078927], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
genes
[gene|464DD1855E6B3195EE242637612A16C73FF32FC0|psdA]-[gene|AC7F08DC1DF7DD2F9AFF84041D357B286B1244AC|psdB]
description
[Pubmed|18394148]
regulation
''[protein|search|psdA]'': induced by nisin, gallidermin ([protein|search|PsdR]) [Pubmed|21078927]
Biological materials
Mutant
MGNA-B635 (yvcR::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1634 NBRP B. subtilis, Japan]
BKE34700 ([gene|464DD1855E6B3195EE242637612A16C73FF32FC0|psdA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE34700 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTCTGCTCCTCCTTTT, downstream forward: _UP4_TTGAGTGTGTTGGGAGGCGA
BKK34700 ([gene|464DD1855E6B3195EE242637612A16C73FF32FC0|psdA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK34700 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTCTGCTCCTCCTTTT, downstream forward: _UP4_TTGAGTGTGTTGGGAGGCGA
References
Reviews
Original Publications
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Time of last update: 2024-12-31 00:08:59
Author of last update: Jstuelk