rpmA

rpmA
168

ribosomal protein bL27

locus
BSU_27940
Molecular weight
10.23 kDa
pI
10.76
Protein length
Gene length
function
translation
product
ribosomal protein L27 (bL27)
essential
yes
synonyms
rpmA

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0211 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,854,880  2,855,164
Phenotypes of a mutant
essential [Pubmed|23002217,12682299]
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The protein
Protein family
bacterial [wiki|ribosomal protein] bL27 family (single member, according to UniProt)
Structure
[PDB|3J9W] (the [wiki|ribosome]) [Pubmed|25903689]
[AF|P05657]
Modification
the N-terminal extension is cleaved off by [protein|B27548A4BBF396C9BA102A80ACB08B21262CEA30|prp] [Pubmed|25388641]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Additional information
the protein is significantly underrepresented in 45S assembly intermediates that accumulate upon depletion of [protein|54CD247926F7FABE4ACE85EB7021B62500B47260|rbgA] [Pubmed|24335279]
Expression and Regulation
Operons
genes
[gene|11927EB0448839D047EC7BF70EC65156DAB481D3|rplU]-[gene|B27548A4BBF396C9BA102A80ACB08B21262CEA30|prp]-[gene|4626C659D6F1A81CCC94030F1CBAF7FEC3DE19CA|rpmA]
description
[Pubmed|22383849]
regulation
[protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|rel] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
likely autorepression of the [gene|11927EB0448839D047EC7BF70EC65156DAB481D3|rplU]→[gene|4626C659D6F1A81CCC94030F1CBAF7FEC3DE19CA|rpmA] operon expression upon binding of excess of one ribosomal protein to the untranslated region of the [gene|11927EB0448839D047EC7BF70EC65156DAB481D3|rplU]→[gene|4626C659D6F1A81CCC94030F1CBAF7FEC3DE19CA|rpmA] mRNA [Pubmed|17616982]
regulatory mechanism
stringent response: negative regulation, in [regulon|other_regulator:stringent response|stringent response]
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[gene|11927EB0448839D047EC7BF70EC65156DAB481D3|rplU]→[gene|4626C659D6F1A81CCC94030F1CBAF7FEC3DE19CA|rpmA]

2024-06-30 04:03:55

Jstuelk

86

8f3fdba1f688b7c526a0b1e5093a21e24d385eba

2B427CEB8C26458F794890CD1011223BA52E2EDB

genes
[gene|AB2A3422277040107AAF90358BBE58608F8E0738|spoIVFA]-[gene|8801B095C2CE36F3E0B9DBBF489FFB217087DC0A|spoIVFB]-[gene|11927EB0448839D047EC7BF70EC65156DAB481D3|rplU]-[gene|B27548A4BBF396C9BA102A80ACB08B21262CEA30|prp]-[gene|4626C659D6F1A81CCC94030F1CBAF7FEC3DE19CA|rpmA]
description
[Pubmed|22383849]
regulation
expressed early during sporulation in the mother cell ([protein|search|SigE], [wiki|SpoIIID]) [Pubmed|15699190,1942049,15383836]
additional information
the domains that inhibits [protein|search|SpoIVFB] is cleaved off by [protein|search|CtpB] (second cleavage) [PubMed|24243021]
Open in new tab

[gene|AB2A3422277040107AAF90358BBE58608F8E0738|spoIVFA]→[gene|4626C659D6F1A81CCC94030F1CBAF7FEC3DE19CA|rpmA]

2024-05-26 14:30:26

ghost

96

08f2f6d702f3f60218799ff9efc97a2139d25593

976520A55B5743F327D2763CEA04F353CE09CEE1

genes
[gene|4626C659D6F1A81CCC94030F1CBAF7FEC3DE19CA|rpmA]
description
[Pubmed|8969504]
Open in new tab

[gene|4626C659D6F1A81CCC94030F1CBAF7FEC3DE19CA|rpmA]

2024-06-13 12:30:52

ghost

48

e286d691a24d7fb78732ca8a4f66332c66864322

B723CB390409E8774002664AACE72A997C1D07F0

References
36815589,19653700,8969504,23002217,24335279,25388641,22383849,25903689,28516784

4626C659D6F1A81CCC94030F1CBAF7FEC3DE19CA

Page visits: 4528

Time of last update: 2024-07-15 03:49:02

Author of last update: Jstuelk