ugd
168
UDP-glucose dehydrogenase
locus
BSU_36230
Molecular weight
47.62 kDa
pI
5.03
function
unknown
product
UDP-glucose dehydrogenase
essential
no
ec
1.1.1.22
synonyms
ugd, ywqF
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1004 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,729,488 3,730,810
The protein
Catalyzed reaction/ biological activity
H2O + 2 NAD+ + UDP-α-D-glucose --> 3 H+ + 2 NADH + UDP-α-D-glucuronate (according to UniProt)
Protein family
UDP-glucose/GDP-mannose dehydrogenase family (with [protein|DF8CD0B3997A7A4CF4821A7D64E9898422FD17E0|tuaD] and [protein|59024C05AA0106719C81E45E3B060A6F710B2690|ytcA], according to UniProt)
Structure
[PDB|3GG2] (from Porphyromonas gingivalis, 45% identity)
[AF|P96718]
Modification
phosphorylation on Tyr-70 by [protein|6100EA37592A2C31BC3DE79AD7948A8D6F65F6E1|ptkA] [Pubmed|12970183], dephosphorylated by [protein|CF73D86DB024575BE8F043A4C3996458F4262E46|ptpZ] [Pubmed|15866923]
Effectors of protein activity
phosphorylation by [protein|6100EA37592A2C31BC3DE79AD7948A8D6F65F6E1|ptkA] stimulates activity of Ugd [Pubmed|15741737]
Paralogous protein(s)
[protein|59024C05AA0106719C81E45E3B060A6F710B2690|ytcA], [protein|DF8CD0B3997A7A4CF4821A7D64E9898422FD17E0|tuaD]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|8DCA50478136628DD9E5D01E89609A686EED9F57|tkmA]-[gene|6100EA37592A2C31BC3DE79AD7948A8D6F65F6E1|ptkA]-[gene|CF73D86DB024575BE8F043A4C3996458F4262E46|ptpZ]-[gene|45AFD434F5262BFBE4ED6DF3D18DAED61FF317D1|ugd]
description
[Pubmed|20815827,12970183]
regulatory mechanism
[protein|2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A]: activation, [Pubmed|26283769], in [regulon|protein:2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A regulon]
[protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|degU]: activation, [protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|degU]-P, [Pubmed|26283769], in [regulon|protein:D343D2096664A972026D911E7A17A35C7B1CD1C9|degU regulon]
[protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]: repression, [Pubmed|20817675], in [regulon|protein:E5110D9C36E8C55AFD1419987B14A53232165F20|abrB regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|20815827], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
BKE36230 ([gene|45AFD434F5262BFBE4ED6DF3D18DAED61FF317D1|ugd]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE36230 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGTTTCCCTCCAACAGT, downstream forward: _UP4_TAGATGAAAAAGAAAGGCTG
References
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Time of last update: 2024-12-22 03:51:57
Author of last update: Melvin.boenninger