fabG
168
beta-ketoacyl-acyl carrier protein reductase
locus
BSU_15910
Molecular weight
26.13 kDa
pI
8.09
function
fatty acid biosynthesis
product
beta-ketoacyl-acyl carrier protein reductase
essential
yes
ec
1.1.1.100
synonyms
fabG, ylpF
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1028 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,664,513 1,665,253
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
(3R)-hydroxyacyl-[ACP] + NADP+ --> 3-oxoacyl-[ACP] + H+ + NADPH (according to UniProt)
Protein family
[wiki|Short-chain dehydrogenases/reductases (SDR) family] (according to UniProt)
Structure
[PDB|2UVD] (the enzyme from ''B. anthracis'', 73% identity) [pubmed|17894349]
[AF|P51831]
Paralogous protein(s)
[protein|4DEFC2998464BF8327578C36A13A10DD277F991E|ykvO], [protein|6047F2493FCE3D2A9BDB1AD88E5926ECEED81036|yhxC], [protein|652A1CC7F6D33E2C9032E557FAF34B5A828CD441|yusS], [protein|6BA346D8A7B496F9618AFAB4FEEF4BD1A41D2C7E|yoxD], [protein|739B228743BC1FE9E6888E999BC0E4F615E36F9E|yhxD], [protein|B6FF689E65906186F3576B378650D713DB84EDDA|ycdF], [protein|EAEEA4DD9641919830A81185333A2610B964D37C|yhdF]
[protein|D9D1FCBFC62F93CAA34DF61A784406F4E9EE6768|yjdA], (30%)
[protein|248F0805272FED9B38ECBB31E2872BC9EC163CE0|ymfI], (34%)
[protein|3161519994609DA9360ED6E073E4A4C8C6210EFB|ydaD], (31.1%)
[protein|3BF3EC6B3139744D968B2FF18CBEEEF15B591AFF|ytkK], (32,1%)
Expression and Regulation
Operons
genes
[gene|FCDE900167AE36377979E0CF7BC33C7F351B95D3|fapR]-[gene|8F5612395EBF90BEF4C80056EECAFC572384E7F8|plsX]-[gene|BB8542A6444564B21FF5DB6E2C75192C6DA2DFB8|fabD]-[gene|439B468A13137000FB42E9389391CB4986FFED84|fabG]-[gene|8D260693D0C69442BCB9F3D8480E8425ACFE34D2|acpA]
description
[Pubmed|19850612]
regulation
''[protein|FCDE900167AE36377979E0CF7BC33C7F351B95D3|fapR]'': repressed in the absence of malonyl-CoA or malonyl-[protein|8D260693D0C69442BCB9F3D8480E8425ACFE34D2|ACP] ([protein|FCDE900167AE36377979E0CF7BC33C7F351B95D3|fapR]) [Pubmed|12737802]
expression is reduced in motile cells as compared to non-motile cells [pubmed|33782055]
regulatory mechanism
[protein|FCDE900167AE36377979E0CF7BC33C7F351B95D3|fapR]: repression, [Pubmed|12737802], in [regulon|protein:FCDE900167AE36377979E0CF7BC33C7F351B95D3|fapR regulon]
[protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|comA]: activation, ([protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|comA]) [Pubmed|16091051], in [regulon|protein:7832489F11F606BCF637EC23BAAB41AD10237EBB|comA regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|16932747], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
the mRNA is cleaved by [protein|BAB297D18F94FFA67B8D12A684AB4D1BCDFB4981|RNase III] [PubMed|26883633]
References
Reviews
Original Publications
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Time of last update: 2024-12-31 01:54:57
Author of last update: Melvin.boenninger