mltG
168
lytic tranglycosylases, potential terminase for peptidoglycan polymerization
locus
BSU_27370
Molecular weight
40.34 kDa
pI
9.65
function
determination of peptidoglycan chain length
product
lytic tranglycosylases
essential
no
synonyms
yrrL
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1559 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,795,887 2,796,969
The protein
Catalyzed reaction/ biological activity
endolytic transglycosylase [Pubmed|26507882]
competes with the transpeptidase activity of class A PBPs [pubmed|34036206]
produces glycan strands with a length of 7 disaccharide units from cleavage in the nascent strands [pubmed|34036206]
cleaves the nascent strands to produce short glycan strands that are used in the cell for a yet unknown process [pubmed|34036206]
Protein family
transglycosylase MltG family (single member, according to UniProt)
Structure
[PDB|4IIW] (from ''L. monocytogenes'', 51% identity)
[AF|O34758]
Expression and Regulation
Operons
genes
[gene|41BCD18A1C2D0C69D4445BE14D4617CC61FB23BF|mltG]
description
[Pubmed|22383849]
regulation
repressed under conditions that trigger sporulation ([wiki|Spo0A]) [Pubmed|14651647]
regulatory mechanism
[protein|2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A]: repression, [Pubmed|14651647], in [regulon|protein:2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A regulon]
Biological materials
Mutant
MGNA-A854 (yrrL::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/854 NBRP B. subtilis, Japan]
BKE27370 ([gene|41BCD18A1C2D0C69D4445BE14D4617CC61FB23BF|mltG]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE27370 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTAGGTCTCCTCCCATCA, downstream forward: _UP4_TAAAAGGAGAGCAAAAAGCT
BKK27370 ([gene|41BCD18A1C2D0C69D4445BE14D4617CC61FB23BF|mltG]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK27370 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTAGGTCTCCTCCCATCA, downstream forward: _UP4_TAAAAGGAGAGCAAAAAGCT
References
Reviews
Original Publications
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Time of last update: 2024-12-22 00:12:21
Author of last update: Jstuelk