mltG

mltG
168

lytic tranglycosylases, potential terminase for peptidoglycan polymerization

locus
BSU_27370
Molecular weight
40.34 kDa
pI
9.65
Protein length
Gene length
function
determination of peptidoglycan chain length
product
lytic tranglycosylases
essential
no
synonyms
yrrL

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1559 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,795,887  2,796,969
The protein
Catalyzed reaction/ biological activity
endolytic transglycosylase [Pubmed|26507882]
competes with the transpeptidase activity of class A PBPs [pubmed|34036206]
produces glycan strands with a length of 7 disaccharide units from cleavage in the nascent strands [pubmed|34036206]
cleaves the nascent strands to produce short glycan strands that are used in the cell for a yet unknown process [pubmed|34036206]
Protein family
transglycosylase MltG family (single member, according to UniProt)
Structure
[PDB|4IIW] (from ''L. monocytogenes'', 51% identity)
[AF|O34758]
Expression and Regulation
Operons
genes
[gene|41BCD18A1C2D0C69D4445BE14D4617CC61FB23BF|mltG]
description
[Pubmed|22383849]
regulation
repressed under conditions that trigger sporulation ([wiki|Spo0A]) [Pubmed|14651647]
regulatory mechanism
[protein|2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A]: repression, [Pubmed|14651647], in [regulon|protein:2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A regulon]
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[gene|41BCD18A1C2D0C69D4445BE14D4617CC61FB23BF|mltG]

2024-09-23 21:42:59

ghost

76

1b1d0dc6a77ce8a2642d0397bc4069a32ef4d4f8

63E816D1063A564D4B75A6A9FFE47C46D1907A6A

Biological materials
Mutant
MGNA-A854 (yrrL::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/854 NBRP B. subtilis, Japan]
BKE27370 ([gene|41BCD18A1C2D0C69D4445BE14D4617CC61FB23BF|mltG]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE27370 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTAGGTCTCCTCCCATCA,  downstream forward: _UP4_TAAAAGGAGAGCAAAAAGCT
BKK27370 ([gene|41BCD18A1C2D0C69D4445BE14D4617CC61FB23BF|mltG]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK27370 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTAGGTCTCCTCCCATCA,  downstream forward: _UP4_TAAAAGGAGAGCAAAAAGCT
References
Reviews
33709487
Original Publications
14651647,26507882,34036206

41BCD18A1C2D0C69D4445BE14D4617CC61FB23BF

Page visits: 2398

Time of last update: 2024-10-09 20:20:28

Author of last update: Jstuelk