pyrH
168
uridylate kinase
locus
BSU_16510
Molecular weight
25.93 kDa
pI
5.1
function
pyrimidine biosynthesis
product
uridylate kinase
essential
yes
ec
2.7.4.22
synonyms
pyrH, smbA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0528 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,719,802 1,720,524
Phenotypes of a mutant
essential [Pubmed|28189581]
The protein
Catalyzed reaction/ biological activity
ATP + UMP --> ADP + UDP (according to UniProt)
Protein family
UMP kinase family (single member, according to UniProt)
Structure
[PDB|2JJX] (from ''Bacillus anthracis'', 42% identity, 64% similarity) [Pubmed|18625239]
[AF|O31749]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|F1969E4C7BAAF70BCBE570F58350C12A3E417539|rpsB]-[gene|94E1130A787CBCCCDBDA93C8AFC24ECB82D5FE61|tsf]-[gene|40655595D0C573B4CB75FB255CBB01A6ACF1F94D|pyrH]-[gene|093960C48AD50C0D0B3A68BBFE7D060BE716935D|frr]
description
[pubmed|22383849]
regulation
[protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|rel] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
regulatory mechanism
stringent response: negative regulation, [pubmed|11948165], in [regulon|other_regulator:stringent response|stringent response]
References
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Time of last update: 2024-10-03 00:01:26
Author of last update: Melvin.boenninger