valS

valS
168

valyl-tRNA synthetase

locus
BSU_28090
Molecular weight
101.55 kDa
pI
4.87
Protein length
Gene length
function
translation
product
valyl-tRNA synthetase
essential
yes
ec
6.1.1.9
synonyms
valS

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0525 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,866,664 2,869,306
Phenotypes of a mutant
essential [Pubmed|12682299]
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The protein
Catalyzed reaction/ biological activity
ATP + L-valine + tRNA(Val) --> AMP + diphosphate + L-valyl-tRNA(Val) (according to UniProt)
Protein family
[wiki|Class-I aminoacyl-tRNA synthetase family] (according to UniProt)
Structure
[PDB|1IYW] (from ''Thermus thermophilus'', 41% identity, 60% similarity) [Pubmed|12554880]
[AF|Q05873]
Additional information
belongs to the 100 most abundant proteins [PubMed|15378759]
Expression and Regulation
Operons
genes
[gene|3E84B3AC08D0B314286CEF38534BD81B568F3E0E|valS]-[gene|80502F76F076C08CCE702F25095C06D14CD8154A|folC]
description
[Pubmed|9098041]
regulation
induced by valine limitation ([wiki|T-box]) [Pubmed|9098041,19258532]
the [wiki|T-box] RNA is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [pubmed|29794222]
regulatory mechanism
T-box: RNA switch, via [wiki|riboswitch], in [regulon|other_regulator:T-box|T-box]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|9098041], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|3E84B3AC08D0B314286CEF38534BD81B568F3E0E|valS]→[gene|80502F76F076C08CCE702F25095C06D14CD8154A|folC]

2024-05-21 11:02:36

Jstuelk

60

64c7b11f4878aed4c36d2e4e2b9cae27833cf315

A1C4330DE465178FB476B238AAC55A673B909A2E

References
Reviews
19258532
Original Publications
9098041,15378759,25310979,29794222

3E84B3AC08D0B314286CEF38534BD81B568F3E0E

Page visits: 2709

Time of last update: 2024-05-22 22:25:45

Author of last update: Melvin.boenninger