yhaO
168
similar to DNA double-strand break repair protein
locus
BSU_09910
Molecular weight
46.65 kDa
pI
5.23
function
unknown
product
unknown
essential
no
synonyms
yhaO, sbcF
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0420 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,064,846 1,066,072
Phenotypes of a mutant
enhanced formation of [gene|F1969E4C7BAAF70BCBE570F58350C12A3E417539|rpsB] or [gene|144D952B05EBBFF41EC92DF906543EA00475FE69|rpsE] suppressor mutants after mitomycin treatment [pubmed|34339280]
The protein
Protein family
[wiki|Metallophosphoesterase superfamily] (according to UniProt)
Structure
[PDB|4TUG] (from Methanocaldococcus jannaschii, corresponds to aa 5 - 290, 27% identity) [pubmed|25107472]
[AF|O07522]
[wiki|Localization]
cytoplasm (Homogeneous) [Pubmed|16479537]
Expression and Regulation
Operons
genes
[gene|3E27C881BB3DE3FD55B7AD21B8771A859D80786F|yhaO]-[gene|709C4D0AE9C78C9A367F37B9C3B37D2516850D7C|sbcE]-[gene|6D585EB5E56A1E5C1C31680D960043BA08C817E2|yhaM]
description
[Pubmed|16267290]
regulation
induced by DNA damage ([protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA]) [Pubmed|16267290]
regulatory mechanism
[protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA]: repression, [Pubmed|16267290], in [regulon|protein:D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA regulon]
Biological materials
Mutant
MGNA-A664 (yhaO::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/664 NBRP B. subtilis, Japan]
BKE09910 ([gene|3E27C881BB3DE3FD55B7AD21B8771A859D80786F|yhaO]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE09910 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCTGCTCCTTTCCAGGA, downstream forward: _UP4_CTTAAGGTGCTTGATACATG
BKK09910 ([gene|3E27C881BB3DE3FD55B7AD21B8771A859D80786F|yhaO]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK09910 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCTGCTCCTTTCCAGGA, downstream forward: _UP4_CTTAAGGTGCTTGATACATG
References
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Time of last update: 2025-01-19 09:36:52
Author of last update: Jstuelk