fhuB
168
hydroxamate siderophore [wiki|ABC transporter] (ferrichrome und ferrioxamine) (permease)
locus
BSU_33310
Molecular weight
40.56 kDa
pI
10.14
function
siderophore uptake
product
hydroxamate siderophore [wiki|ABC transporter ](ferrichrome und ferrioxamine) (permease)
essential
no
synonyms
fhuB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0609 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,417,222 3,418,376
The protein
Protein family
[wiki|Binding-protein-dependent transport system permease family] (according to UniProt)
[wiki|FecCD subfamily] (according to UniProt)
Structure
[PDB|4G1U] (from Yersinia pestis, 37% identity) [pubmed|23142986]
[AF|P49936]
Paralogous protein(s)
[protein|57402D137E3D3791CAF0696421224F4E1DC1BA48|feuB], [protein|81494D4E7E52531802C3C0D0073739DA9375F5DF|yfiZ], [protein|BDAA56484E05DA3C1CB0CA09873A365657999679|fecD]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|3E1C925C31C00803982C8EB1C6B025C22DB4A828|fhuB]-[gene|EC98685EE0E3CE6CE8DC33409481AE96315279AC|fhuG]-[gene|E70BE74D5AB4B06CDFF902E58A0B9EBF477E21EC|fhuC]
description
[pubmed|22383849]
regulation
induced by iron starvation (second wave to allow iron scavenging from the environment) ([protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur]) [pubmed|29133393,12354229]
regulatory mechanism
[protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur]: repression, [pubmed|12354229], in [regulon|protein:F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur regulon]
Biological materials
Mutant
BKE33310 ([gene|3E1C925C31C00803982C8EB1C6B025C22DB4A828|fhuB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE33310 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTGCAAAAATATCGTGT, downstream forward: _UP4_CGTCGTGAAAGGAGAGGGCT
BKK33310 ([gene|3E1C925C31C00803982C8EB1C6B025C22DB4A828|fhuB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK33310 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTGCAAAAATATCGTGT, downstream forward: _UP4_CGTCGTGAAAGGAGAGGGCT
References
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Time of last update: 2024-10-10 17:11:06
Author of last update: Melvin.boenninger