efeU
168
elemental iron uptake system (permease), high affinity uptake of ferric iron (Fe(III))
locus
BSU_38280
Molecular weight
52.24 kDa
pI
8.96
function
elemental iron uptake
product
elemental iron uptake system (permease)
essential
no
synonyms
efeU, ywbL
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0672 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,929,105 3,930,550
Phenotypes of a mutant
no growth with ferric iron (Fe3+) as the sole source of iron [pubmed|23764491]
The protein
Protein family
Oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family (single member, according to UniProt)
Structure
[AF|P39595]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|3BED98E311EF380AE77327C7F0A83254805089C0|efeU]-[gene|B31884DC49684A276D65E21A5F59AFDADEB9749C|efeO]-[gene|3985F88334D7B034A66473C5BB39188AB61A65F6|efeB]
description
[Pubmed|9353933]
regulation
immediately induced upon iron starvation (first wave to allow iron uptake) ([protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur]) [Pubmed|29133393,12354229]
regulatory mechanism
[protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur]: repression, [pubmed|12354229], in [regulon|protein:F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|23764491], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
MGNA-B226 (ywbL::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1225 NBRP B. subtilis, Japan]
BKE38280 ([gene|3BED98E311EF380AE77327C7F0A83254805089C0|efeU]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE38280 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCATGTTCCTCCTATAAT, downstream forward: _UP4_ACAAACGGAAAGGAACTGAC
BKK38280 ([gene|3BED98E311EF380AE77327C7F0A83254805089C0|efeU]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK38280 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCATGTTCCTCCTATAAT, downstream forward: _UP4_ACAAACGGAAAGGAACTGAC
References
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Time of last update: 2025-04-01 20:18:36
Author of last update: Jstuelk