phoB

phoB
168

alkaline phosphatase III, heptaprenylglyceryl phosphate processing phosphatase

locus
BSU_05740
Molecular weight
50.36 kDa
pI
5.89
Protein length
Gene length
function
aquisition of phosphate upon phosphate starvation, ether lipid synthesis
product
alkaline phosphatase III, heptaprenylglyceryl phosphate processing phosphatase
essential
no
ec
3.1.3.1
synonyms
phoB

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1785 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
620,097  621,485
The protein
Catalyzed reaction/ biological activity
phosphate monoester + H2O --> alcohol + phosphate (according to UniProt)
Protein family
alkaline phosphatase family (with [protein|E0430C16C41440633647976A0F9183E24268E198|phoA], according to UniProt)
Structure
[PDB|3A52] (from ''Shewanella sp.'', 41% identity) [Pubmed|20057143]
[AF|P19405]
Modification
phosphorylated on ser/ thr/ tyr [Pubmed|16493705]
Paralogous protein(s)
[protein|E0430C16C41440633647976A0F9183E24268E198|phoA]
[wiki|Localization]
extracellular (signal peptide) [Pubmed|18957862]
Expression and Regulation
Operons
genes
[gene|3B95AB3021280215B6B487A348D78FB5797AEEA6|phoB]-[gene|66D3E978E3DBA0410CA5597B5B860DF27C97335A|ydhF]
description
[Pubmed|10913081]
regulation
expressed under conditions of phosphate limitation ([protein|search|PhoP]) [Pubmed|9335276,10913081,16030210]
regulatory mechanism
[protein|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|phoP]: activation, [Pubmed|9335276,10913081,16030210], in [regulon|protein:638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|phoP regulon]
sigma factors
[protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]: sigma factor, [Pubmed|15699190,16030210], in [regulon|protein:3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE regulon]
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Open in new tab

[gene|3B95AB3021280215B6B487A348D78FB5797AEEA6|phoB]→[gene|66D3E978E3DBA0410CA5597B5B860DF27C97335A|ydhF]

2024-12-21 14:36:01

ghost

66

cf8fae553be5c06d43c84ce2a1d3a9b12b8fcea3

B70A2379ADCCEACE613557232251C41C729E999D

Biological materials
Mutant
1A767 ( ''phoB''::''cat''), [Pubmed|9426145], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A767&Search=1A767 BGSC]
BKE05740 ([gene|3B95AB3021280215B6B487A348D78FB5797AEEA6|phoB]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE05740 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAACTGGATAACCTCCTAAA,  downstream forward: _UP4_TAAAAGAATACAAGGTGTCC
BKK05740 ([gene|3B95AB3021280215B6B487A348D78FB5797AEEA6|phoB]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK05740 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAACTGGATAACCTCCTAAA,  downstream forward: _UP4_TAAAAGAATACAAGGTGTCC
References
16030210,9335276,8088554,10913081,16491025,8113174,9335276,18957862,16493705,25666134,20057143,27118079,27226549

3B95AB3021280215B6B487A348D78FB5797AEEA6

Page visits: 8381

Time of last update: 2024-12-20 20:35:49

Author of last update: Melvin.boenninger