phrG
168
response regulator aspartate phosphatase (RapG) regulator
locus
BSU_40310
Molecular weight
4.04 kDa
pI
9.02
function
control of DegU activity
product
phosphatase (RapG) regulator
essential
no
ec
null
synonyms
phrG, yycL
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms
This gene is a member of the following regulons
Gene
Coordinates
4,141,358 4,141,474
The protein
Catalyzed reaction/ biological activity
binds to [protein|E1744329B6489F989F93F3E71E51E772E3926ABF|rapG], this results in the inability of [protein|E1744329B6489F989F93F3E71E51E772E3926ABF|rapG] to interact with [protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|degU] [Pubmed|12950930]
Protein family
[wiki|phr family] (according to UniProt)
Structure
[AF|O32295]
Expression and Regulation
Operons
genes
[gene|E1744329B6489F989F93F3E71E51E772E3926ABF|rapG]-[gene|3B4E60C698B8E4FA286E06B934EC0CEDD5F516A5|phrG]
description
[Pubmed|12950930]
regulation
repressed by glucose (4.8-fold) ([protein|search|CcpA]) [Pubmed|12850135]
regulatory mechanism
[protein|5A6FBAE6553343092862CB79E150F934978C32A9|sinR]: repression, [Pubmed|16430695], in [regulon|protein:5A6FBAE6553343092862CB79E150F934978C32A9|sinR regulon]
[protein|972401B6AF56EC67FE6F1C3FEA9E2A9FC77C7672|rghR]: repression, [Pubmed|16553878], in [regulon|protein:972401B6AF56EC67FE6F1C3FEA9E2A9FC77C7672|rghR regulon]
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|12850135], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|16553878], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[protein|DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|sigH]: sigma factor, [Pubmed|12950930], in [regulon|protein:DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|sigH regulon]
Biological materials
Mutant
MGNA-B822 (yycL::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1821 NBRP B. subtilis, Japan]
BKE40310 ([gene|3B4E60C698B8E4FA286E06B934EC0CEDD5F516A5|phrG]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE40310 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TGCGCCAATCAGAAATCTTT, downstream forward: _UP4_TAAATGAAAAACCCCCGCGG
BKK40310 ([gene|3B4E60C698B8E4FA286E06B934EC0CEDD5F516A5|phrG]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK40310 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TGCGCCAATCAGAAATCTTT, downstream forward: _UP4_TAAATGAAAAACCCCCGCGG
References
Reviews
Original Publications
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Time of last update: 2024-12-21 08:17:33
Author of last update: Jstuelk