apt
168
adenine phosphoribosyltransferase, universally conserved protein
locus
BSU_27610
Molecular weight
18.73 kDa
pI
4.7
function
purine salvage and interconversion
product
adenine phosphoribosyltransferase
essential
no
ec
2.4.2.7
synonyms
apt
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0503 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,822,901 2,823,413
The protein
Catalyzed reaction/ biological activity
AMP + diphosphate --> 5-phospho-α-D-ribose 1-diphosphate + adenine (according to UniProt)
Protein family
[wiki|Purine/pyrimidine phosphoribosyltransferase family] (according to UniProt)
Structure
[PDB|2DY0] (from ''Escherichia coli k12'', 56% identity, 66% similarity)
[AF|O34443]
Modification
phosphorylated on Arg-85 [Pubmed|22517742]
Additional information
[wiki|universally conserved protein]
Expression and Regulation
Operons
genes
[gene|BA755FA1CB1E0C006E9A23489A7C8997141AA498|recJ]-[gene|38DF74800FC5D54183C58B0EB82BD9A3EB93EE33|apt]
description
[Pubmed|15241682]
regulation
[protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|rel] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
regulatory mechanism
stringent response: negative regulation, in [regulon|other_regulator:stringent response|stringent response]
Biological materials
Mutant
BKE27610 ([gene|38DF74800FC5D54183C58B0EB82BD9A3EB93EE33|apt]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE27610 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GTATTGTTTTAAATCCATCT, downstream forward: _UP4_TAAGGATAACCGCATAACGA
BKK27610 ([gene|38DF74800FC5D54183C58B0EB82BD9A3EB93EE33|apt]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK27610 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GTATTGTTTTAAATCCATCT, downstream forward: _UP4_TAAGGATAACCGCATAACGA
References
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Time of last update: 2024-10-07 06:52:56
Author of last update: Melvin.boenninger