lnrK
168
two-component response regulator, involved in resistance to linearmycin
locus
BSU_08300
Molecular weight
24.22 kDa
pI
4.67
function
resistance to linearmycin
product
two-component response regulator
essential
no
synonyms
lnrK, yfiK
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2197 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
905,010 905,672
The protein
[wiki|Domains]
[wiki|Response regulatory domain] (aa 3-119) (according to UniProt)
[wiki|HTH luxR-type domain] (aa 151-216) (according to UniProt)
Structure
[PDB|5HEV] ([protein|search|LiaR ]from Enterococcus faecium, 42% identity) [pubmed|27670715]
[AF|P94439]
Modification
phosphorylated by [protein|03AEADB134F1CAD8BBB3E1F625D597EBA1FDA30B|lnrJ] on an Asp residue
Paralogous protein(s)
[protein|49E70A20CC05DBE485953C0AE34E634EFB33C3B2|liaR], [protein|DD799ED3EB79457C27ED30C7B4DBBC2C8F962191|yhcZ], [protein|EFEAF09E4449A022A7323450FDED9458426A0080|ydfI], [protein|23F365C23BDEE02D42C9355FC7D2A65DAF9F79ED|yxjL]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|03AEADB134F1CAD8BBB3E1F625D597EBA1FDA30B|lnrJ]-[gene|387EF370CE24F7A3C20789A57329A02EBED46F53|lnrK]
description
[Pubmed|8973323]
Biological materials
Mutant
MGNA-C301 (yfiK::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2299 NBRP B. subtilis, Japan]
BKE08300 ([gene|387EF370CE24F7A3C20789A57329A02EBED46F53|lnrK]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE08300 BGSC], [Pubmed|28189581], upstream reverse: _UP1_ATCGTCGGTAATGATGATCT, downstream forward: _UP4_TGACATATGACGTTTTGCAT
BKK08300 ([gene|387EF370CE24F7A3C20789A57329A02EBED46F53|lnrK]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK08300 BGSC], [Pubmed|28189581], upstream reverse: _UP1_ATCGTCGGTAATGATGATCT, downstream forward: _UP4_TGACATATGACGTTTTGCAT
References
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Time of last update: 2024-12-21 15:31:15
Author of last update: Jstuelk