menA
168
probable 1,4-dihydroxy-2-naphthoate octaprenyltransferase
locus
BSU_38490
Molecular weight
33.68 kDa
pI
9.32
function
biosynthesis of menaquinone
product
probable 1,4-dihydroxy-2-naphthoate octaprenyltransferase
essential
yes
ec
2.5.1.74
synonyms
menA, ywaB, ipa-6d
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1575 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,950,726 3,951,661
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
1,4-dihydroxy-2-naphthoate + all-trans-polyprenyl diphosphate + H+ --> 2-demethylmenaquinol + CO2 + diphosphate (according to UniProt)
Protein family
MenA family (single member, according to UniProt)
Structure
[PDB|3BYV] (from ''Toxoplasma gondii'', 30% identity in a 25% fragment) [Pubmed|19197235]
[AF|P39582]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|34DBBDD76A0B36867E5116FF17391DF70062F745|menA]
description
[Pubmed|9353933]
regulation
the leader mRNA is processed by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y], this requires the [protein|EE52DFA35B935E551871D079A9BE877DB2001A3B|ricA]-[protein|6C9A092F38739A3759793EF8B496569CD02C2E3F|ricF]-[protein|EBD15C174A03B7FCDFFE4C5DB5D86E93F1B9CAC4|ricT] complex [Pubmed|29794222]
Biological materials
Mutant
MGNA-B217 (ywaB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1216 NBRP B. subtilis, Japan]
References
Page visits: 3155
Time of last update: 2024-12-20 17:21:35
Author of last update: Jstuelk