bltD
168
spermidine/ spermine acetyltransferase
locus
BSU_26600
Molecular weight
17.70 kDa
pI
6.09
function
spermidine degradation
product
spermidine/ spermine acetyltransferase
essential
no
ec
2.3.1.57
synonyms
bltD, bmr2D, bmtD
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1670 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,718,344 2,718,802
The protein
Catalyzed reaction/ biological activity
acetyl-CoA + an alkane-α,ω-diamine --> N-acetylalkane-α,ω-diamine + CoA + H+ (according to UniProt)
[wiki|Domains]
[wiki|N-acetyltransferase domain] (aa 3-152) (according to UniProt)
Structure
[PDB|2FL4] (from Enterococcus faecalis, 45% identity)
[AF|P39909]
Expression and Regulation
Operons
genes
[gene|B7C4BE1A252C6376B28C4FCC6EA9DCF3BC096405|blt]-[gene|34360353D4488F1081FEF9A3CF8F1866D271657D|bltD]
description
[Pubmed|7608059]
regulation
induced in the presence of polyamines [pubmed|29142164]
regulatory mechanism
[protein|507E3E5493A88A0CD4CC0B8BE0EC3FCCA65493C7|bltR]: activation, [Pubmed|7608059], in [regulon|protein:507E3E5493A88A0CD4CC0B8BE0EC3FCCA65493C7|bltR regulon]
[protein|A7326377132C670B60695EFE0A652B1E4F623698|mta]: activation, [Pubmed|10200972], in [regulon|protein:A7326377132C670B60695EFE0A652B1E4F623698|mta regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|10200972], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
MGNA-C455 (bltD::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2453 NBRP B. subtilis, Japan]
BKE26600 ([gene|34360353D4488F1081FEF9A3CF8F1866D271657D|bltD]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE26600 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATACTACATTCTCCTTTTT, downstream forward: _UP4_TAGATATCCAAGCCTCCTTG
BKK26600 ([gene|34360353D4488F1081FEF9A3CF8F1866D271657D|bltD]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK26600 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATACTACATTCTCCTTTTT, downstream forward: _UP4_TAGATATCCAAGCCTCCTTG
References
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Time of last update: 2024-12-19 08:38:53
Author of last update: Melvin.boenninger