hemD
168
uroporphyrinogen-III synthase
locus
BSU_28140
Molecular weight
28.96 kDa
pI
5.09
function
heme biosynthesis
product
uroporphyrinogen-III synthase
essential
no
ec
4.2.1.75
synonyms
hemD
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1587 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,875,173 2,875,961
The protein
Catalyzed reaction/ biological activity
hydroxymethylbilane --> H2O + uroporphyrinogen III (according to UniProt)
Protein family
uroporphyrinogen-III synthase family (single member, according to UniProt)
Structure
[AF|P21248]
Expression and Regulation
Operons
genes
[gene|B1413EB525000744BE8E429E760220A13BC4530D|hemA]-[gene|88616BA1E853E11BE0CB18F06287CA4C68143148|hemX]-[gene|D266E22E07B849E2AEB0EF232C49A2FE1EA4E02B|hemC]-[gene|33459D4389F85D60311FCE770BBA0ED9802BA342|hemD]-[gene|70263A55987F110209367CF45AD65A584AD3077D|hemB]-[gene|A54B2C86638D474F5F892003B42C535B5B39A42E|hemL]
description
[Pubmed|1672867]
regulation
induced by hydrogen peroxide ([protein|search|PerR]) [Pubmed|11532148]
regulatory mechanism
[protein|00BCAAE16576DC5426A652580C69A570FC7A1C2C|perR]: repression, [Pubmed|11532148], in [regulon|protein:00BCAAE16576DC5426A652580C69A570FC7A1C2C|perR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|1672867], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
BKE28140 ([gene|33459D4389F85D60311FCE770BBA0ED9802BA342|hemD]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE28140 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTGTTTTTCCTTTCAACG, downstream forward: _UP4_ATGTCAAGAGAGGAAGAGAG
BKK28140 ([gene|33459D4389F85D60311FCE770BBA0ED9802BA342|hemD]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK28140 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTGTTTTTCCTTTCAACG, downstream forward: _UP4_ATGTCAAGAGAGGAAGAGAG
References
Reviews
Original Publications
Page visits: 1996
Time of last update: 2024-12-30 17:21:15
Author of last update: Melvin.boenninger