ytpP
168
cleavage of CoA moieties from modified proteins, similar to thioredoxin H1
locus
BSU_29840
Molecular weight
12.61 kDa
pI
4.3
function
cleavage of CoA moieties from modified proteins
product
protein deCoAlase
essential
no
synonyms
ytpP
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG3118 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,054,188 3,054,511
The protein
Catalyzed reaction/ biological activity
cleavage of CoA moieties from modified proteins [pubmed|37107313]
[wiki|Domains]
[wiki|Thioredoxin domain] (aa 1-105) (according to UniProt)
Structure
[PDB|4RUV] (Thioredoxin-2 from Staphylococcus aureus, 32% identity)
[AF|O34357]
Expression and Regulation
Operons
genes
[gene|314D5C01B4BDDC3B122F6D4066647B143B2A6543|ytpP]-[gene|886EF2F8A9E031FDF919E01A858C1DBC1AFF1188|ytpQ]-[gene|EE559CD606562097F09DC627F431CA31129D7BC6|ytpR]
description
[Pubmed|21949854]
regulatory mechanism
[protein|2C6386E9A63F410558D168798D077DF91590F454|spx]: activation, [Pubmed|21949854], in [regulon|protein:2C6386E9A63F410558D168798D077DF91590F454|spx regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|21949854], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
MGNA-B531 (ytpP::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1530 NBRP B. subtilis, Japan]
BKE29840 ([gene|314D5C01B4BDDC3B122F6D4066647B143B2A6543|ytpP]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE29840 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTCATATCCCTCCAGTT, downstream forward: _UP4_AAAGCGTAAAGGAGGACATC
BKK29840 ([gene|314D5C01B4BDDC3B122F6D4066647B143B2A6543|ytpP]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK29840 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTCATATCCCTCCAGTT, downstream forward: _UP4_AAAGCGTAAAGGAGGACATC
References
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Time of last update: 2024-10-15 04:12:00
Author of last update: Jstuelk