xerD
168
site-specific integrase/recombinase, partitioning of the terminus region after replication, terminus-specific unloader of translocating SMC complexes
locus
BSU_23510
Molecular weight
33.84 kDa
pI
10
function
chromosome partitioning, unloading of SMC complexes
product
site-specific integrase/recombinase
essential
no
synonyms
ripX, ykqM
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG4974 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,448,591 2,449,481
The protein
Catalyzed reaction/ biological activity
resolution of chromosome dimers by site specific recombination at the dif site (located close to the terminus region on the chromosome)
functions as a site-specific unloader of translocating [protein|0136394A52759CEEDD8DE074ED74033C6FFB8435|smc]-[protein|8DD968C97FDC0E81293887E2FCB7EE1A9416A333|scpA]-[protein|9137D162E6331E2B127472BCF5F49A9AE46266F3|scpB] complexes at the replication terminus [pubmed|33472056]
Protein family
[wiki|phage integrase family] (according to UniProt)
Structure
[PDB|1A0P] (from ''E. coli'', 44% identity, complex with [protein|89746E312F20C81BE3CFDFCE7D99B01C375C198B|codV]) [Pubmed|9311978]
[AF|P46352]
Paralogous protein(s)
[protein|89746E312F20C81BE3CFDFCE7D99B01C375C198B|codV]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
assembles on the chromosome at the dif site throughout the cell cycle [Pubmed|21239579]
Biological materials
Mutant
MGNA-C414 ([gene|301568A5255A31538F52C46D7711EDAB2BD9CE90|xerD]::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2412 NBRP B. subtilis, Japan]
1A793 ( [gene|301568A5255A31538F52C46D7711EDAB2BD9CE90|xerD]::''spec''), [Pubmed| ], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A793&Search=1A793 BGSC]
1A796 ([gene|301568A5255A31538F52C46D7711EDAB2BD9CE90|xerD]::''spec''), [Pubmed|11208805], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A796&Search=1A796 BGSC]
BKE23510 ([gene|301568A5255A31538F52C46D7711EDAB2BD9CE90|xerD]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE23510 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CTTTATTTGATCTTTCACTC, downstream forward: _UP4_TAGCCGCAGGTGGCTGCGGC
BKK23510 ([gene|301568A5255A31538F52C46D7711EDAB2BD9CE90|xerD]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK23510 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CTTTATTTGATCTTTCACTC, downstream forward: _UP4_TAGCCGCAGGTGGCTGCGGC
References
Reviews
Original Publications
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Time of last update: 2024-10-15 12:56:38
Author of last update: Jstuelk