ykpA

ykpA
168

translation factor, housekeeping subfamily F ABC ATPase, prevents ribosome stalling at charged motifs

locus
BSU_14430
Molecular weight
60.88 kDa
pI
4.98
Protein length
540 aaSequenceBlast
Gene length
1623 bpSequenceBlast
function
prevention of ribosome stalling
product
housekeeping subfamily F ABC ATPase
essential
no
synonyms
ykpA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0488 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,512,373  1,513,995
The protein
Catalyzed reaction/ biological activity
promotes translation of otherwise difficult positively or negatively charged amino acid stretches [pubmed|38943426]
Protein family
[wiki|ABC transporter superfamily] (according to UniProt)
[wiki|ABCF ATPase subfamily] [pubmed|30597160]
[wiki|Domains]
2 [wiki|ABC transporter domain]s (aa 2-252, aa 320-537) (according to UniProt)
Structure
[PDB|3J5S] (EttA from E. coli, 33% identity) [pubmed|24389465]
[PDB|4FIN] (EttA from E. coli, 33% identity) [pubmed|24389466]
[AF|O31716]
Paralogous protein(s)
[protein|47B644F334A0BD501E77A198A61CE0F22BAB3E5E|yfmM], [protein|F69F15198ACF8A8347C450EEC09F000EECEDEC41|yfmR], [protein|1F56D3275386BB54A774BFA045C09E36D1268471|ydiF]
Expression and Regulation
Operons
genes
[gene|2F79DB15D359A127C2D833CC0465E18E1725F539|ykpA]
description
[pubmed|22383849]
Open in new tab

[gene|2F79DB15D359A127C2D833CC0465E18E1725F539|ykpA]

2025-01-15 05:53:24

Jstuelk

76

d46d7c78964b64245215f3dbaa93d21d0da28714

19131ABEDBDE935AAB2D2E20061513BB4E99D8C3

genes
[gene|2F79DB15D359A127C2D833CC0465E18E1725F539|ykpA]-[gene|60264E4BE76F5995A8317294D05FC27F8B34E09D|panG]
description
[pubmed|22383849]
Open in new tab

[gene|2F79DB15D359A127C2D833CC0465E18E1725F539|ykpA]→[gene|60264E4BE76F5995A8317294D05FC27F8B34E09D|panG]

2025-01-07 12:21:03

Jstuelk

83

ce96627e6bc3eef0cadea77f88cbe87d581da2c6

A36C5D7B9D14E75C8D85182AA49F8893F8382B7B

Biological materials
Mutant
MGNA-B352 (ykpA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1351 NBRP B. subtilis, Japan]
BKE14430 ([gene|2F79DB15D359A127C2D833CC0465E18E1725F539|ykpA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE14430 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTTATTATCCTCCATCAT,  downstream forward: _UP4_TAAAAAAGCAGAGATTTCTC
BKK14430 ([gene|2F79DB15D359A127C2D833CC0465E18E1725F539|ykpA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK14430 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTTATTATCCTCCATCAT,  downstream forward: _UP4_TAAAAAAGCAGAGATTTCTC
References
Reviews
24500425,30746819,39716376
Original Publications
36815589,10092453,24389466,24389465,27006457,30597160,38943426

2F79DB15D359A127C2D833CC0465E18E1725F539

Page visits: 1992

Time of last update: 2025-01-15 05:50:33

Author of last update: Jstuelk