ndoA

ndoA
168

RNase EndoA, MazF family toxin, UACAU-specific mRNA interferase

locus
BSU_04660
Molecular weight
12.84 kDa
pI
4.89
Protein length
116 aaSequenceBlast
Gene length
351 bpSequenceBlast
function
unknown
product
mRNA interferase
essential
no
synonyms
ndoA, ydcE, mazF
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2337 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
518,943  519,293
The protein
Catalyzed reaction/ biological activity
specifically cleaves a five-base sequence, UACAU [Pubmed|21763692]
Protein family
PemK/MazF family (single member, according to UniProt)
Structure
[PDB|1NE8] [Pubmed|14517982]
[PDB|4MDX] (NdoA-RNA) [Pubmed|24120662]
[PDB|4ME7] ([protein|2E5A557E417CB355331CC0555D46A79793EB90B3|ndoA]-[protein|052BD59112DBE2F1DAC9DA5A7B0EA8DAF8D6FC47|ndoAI] complex) [Pubmed|24120662]
[AF|P96622]
Effectors of protein activity
the activity is inhibited by the interaction with [protein|052BD59112DBE2F1DAC9DA5A7B0EA8DAF8D6FC47|ndoAI] [Pubmed|17416361]
Expression and Regulation
Operons
genes
[gene|052BD59112DBE2F1DAC9DA5A7B0EA8DAF8D6FC47|ndoAI]-[gene|2E5A557E417CB355331CC0555D46A79793EB90B3|ndoA]
description
[Pubmed|15882409]
additional information
An [wiki|ncRNA] is predicted for '[protein|search|ndoA]' [PubMed|20525796]
Open in new tab

[gene|052BD59112DBE2F1DAC9DA5A7B0EA8DAF8D6FC47|ndoAI]→[gene|2E5A557E417CB355331CC0555D46A79793EB90B3|ndoA]

2024-10-04 06:51:04

ghost

59

7f8a7dc2f7eaf781e947a6a63979c438df7e04e3

5DFE68AF98CACE6494FDB04249DEF62EF29E68F8

genes
[gene|CB0B6C69CB5CFF6FE30C3F95991F309C8DE1E344|alr]-[gene|052BD59112DBE2F1DAC9DA5A7B0EA8DAF8D6FC47|ndoAI]-[gene|2E5A557E417CB355331CC0555D46A79793EB90B3|ndoA]
description
[pubmed|22383849]
Open in new tab

[gene|CB0B6C69CB5CFF6FE30C3F95991F309C8DE1E344|alr]→[gene|2E5A557E417CB355331CC0555D46A79793EB90B3|ndoA]

2024-10-07 19:28:52

Jstuelk

65

91b7fa89916159e2bc7894e263572f1eeb4a5554

F1ED0F7D4D8E54352AA236431B9C138B1FC5ADBA

Biological materials
Mutant
BKE04660 ([gene|2E5A557E417CB355331CC0555D46A79793EB90B3|ndoA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE04660 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_ATCGCCGCGTTTCACAATCA,  downstream forward: _UP4_TAGACATATTTGCAGGTTGC
BKK04660 ([gene|2E5A557E417CB355331CC0555D46A79793EB90B3|ndoA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK04660 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_ATCGCCGCGTTTCACAATCA,  downstream forward: _UP4_TAGACATATTTGCAGGTTGC
References
15882409,17416361,20525796,21763692,21897862,23378533,14517982,24120662,24489751,23736285,28017721,38177304,38177302,38199572

2E5A557E417CB355331CC0555D46A79793EB90B3

Page visits: 5078

Time of last update: 2024-10-15 00:06:30

Author of last update: Jstuelk