pgsA

pgsA
168

phosphatidylglycerophosphate synthase

locus
BSU_16920
Molecular weight
21.16 kDa
pI
5.16
Protein length
Gene length
function
biosynthesis of phospholipids
product
phosphatidylglycerophosphate synthase
essential
yes
ec
2.7.8.5
synonyms
pgsA, ymfN

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0558 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,762,623  1,763,204
Phenotypes of a mutant
some point mutations resulting in reduced PgsA activity lead to daptomycin resistance [Pubmed|21709092]essential [Pubmed|12682299]
depletion leads to hypersensitivity to sorbic acid stress [Pubmed|27818647]
The protein
Catalyzed reaction/ biological activity
CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate --> 1,2-diacyl-sn-glycero-3-phospho-(1ʼ-sn-glycero-3ʼ-phosphate) + CMP + H+ (according to UniProt)
Protein family
CDP-alcohol phosphatidyltransferase class-I family (with [protein|DE49797486CEC172F912D26A6BF2223190BF5DAD|pssA], according to UniProt)
Structure
[AF|P46322]
[wiki|Localization]
cell membrane at the septum [Pubmed|19820159,15743965]
Biological materials
Mutant
1A815 ( ''pgsA''::''erm''), [Pubmed|12682299], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A815&Search=1A815 BGSC]
References
19745567,16514141,19820159,15743965,21709092,27818647

2DB0071F2B747A7D5607C7A1B51564C25DC0BA8D

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Time of last update: 2024-10-15 09:36:59

Author of last update: Melvin.boenninger