pgsA
168
phosphatidylglycerophosphate synthase
locus
BSU_16920
Molecular weight
21.16 kDa
pI
5.16
function
biosynthesis of phospholipids
product
phosphatidylglycerophosphate synthase
essential
yes
ec
2.7.8.5
synonyms
pgsA, ymfN
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0558 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,762,623 1,763,204
Phenotypes of a mutant
some point mutations resulting in reduced PgsA activity lead to daptomycin resistance [Pubmed|21709092]essential [Pubmed|12682299]
depletion leads to hypersensitivity to sorbic acid stress [Pubmed|27818647]
The protein
Catalyzed reaction/ biological activity
CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate --> 1,2-diacyl-sn-glycero-3-phospho-(1ʼ-sn-glycero-3ʼ-phosphate) + CMP + H+ (according to UniProt)
Protein family
CDP-alcohol phosphatidyltransferase class-I family (with [protein|DE49797486CEC172F912D26A6BF2223190BF5DAD|pssA], according to UniProt)
Structure
[AF|P46322]
[wiki|Localization]
cell membrane at the septum [Pubmed|19820159,15743965]
Biological materials
Mutant
1A815 ( ''pgsA''::''erm''), [Pubmed|12682299], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A815&Search=1A815 BGSC]
References
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Time of last update: 2024-12-21 01:04:41
Author of last update: Melvin.boenninger