yerI
168
amicoumacin kinase
locus
BSU_06640
Molecular weight
39.18 kDa
pI
4.87
function
resistance to amicoumacin
product
amicoumacin kinase
essential
no
ec
null
synonyms
yerI
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2334 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
724,987 725,997
The protein
Catalyzed reaction/ biological activity
Phosphorylates the antibiotic amicoumacin A (Ami), leading to its inactivation [pubmed|30181282]
Protein family
pseudomonas-type thrB family (single member, according to UniProt)
Structure
[PDB|6EF6] (from Mycobacterium smegmatis, corresponds to aa 17 ... 286, 25% identity) [pubmed|30361441]
[AF|O34640]
Expression and Regulation
Operons
genes
[gene|2AF5F4142F3459A651FCB4057D6B92B9C1D76C6D|yerI]
description
[pubmed|22383849]
regulatory mechanism
[protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]: repression, [Pubmed|20817675], in [regulon|protein:E5110D9C36E8C55AFD1419987B14A53232165F20|abrB regulon]
Biological materials
Mutant
MGNA-A927 (yerI::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/927 NBRP B. subtilis, Japan]
BKE06640 ([gene|2AF5F4142F3459A651FCB4057D6B92B9C1D76C6D|yerI]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE06640 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCCTTTCATTGCTATAGA, downstream forward: _UP4_TAGATAGAAAAAGCCAATGG
BKK06640 ([gene|2AF5F4142F3459A651FCB4057D6B92B9C1D76C6D|yerI]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK06640 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCCTTTCATTGCTATAGA, downstream forward: _UP4_TAGATAGAAAAAGCCAATGG
References
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Time of last update: 2025-04-16 18:11:07
Author of last update: Jstuelk