dnaB
168
initiation of chromosome replication/ membrane attachment protein, part of the [wiki|replisome]
locus
BSU_28990
Molecular weight
54.72 kDa
pI
5.28
function
[category|SW.3.1.1|DNA replication]
product
helicase loader, initiation of chromosome replication/ membrane attachment protein
essential
yes
synonyms
dnaB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG3611 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,964,148 2,965,566
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
binds double-stranded DNA and co-loads the replicative helicase [pubmed|32817095]
Structure
[PDB|5WTN] (from Geobacillus stearothermophilus, 47% identity, N-terminal domain, aa 1 - 300) [pubmed|28808061]
[AF|P07908]
[wiki|Localization]
Membrane-proximal (Spotty) [Pubmed|16479537]
forms foci, close to oriC [Pubmed|10844689]
Expression and Regulation
Operons
genes
[gene|2AEF6D56D884CA6A0BD50FABD27F405DC2B506C7|dnaB]-[gene|AC1B507C6B1640E9BEA1F9F01628120F3680C976|dnaI]-[gene|72A4458679EA1451FA3B63D44C3BE93ACA8B397F|ytxB]-[gene|3EE0D03469D893515CAA4961BF923BE3A6769535|ytxC]-[gene|3E1131CFA3EDEB3865638F09BE2F6B6ED2570BE2|thrS]
description
[Pubmed|22383849]
References
Reviews
Original Publications
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Time of last update: 2024-10-13 03:47:19
Author of last update: Jstuelk