mlpA
168
metallopeptidase, involved in regulation of protease gene expression
locus
BSU_16710
Molecular weight
45.80 kDa
pI
5.28
function
control of proteolytic activity
product
specific processing protease
essential
no
synonyms
mlpA, ymxG
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0612 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,742,617 1,743,846
Phenotypes of a mutant
fivefold increased levels of proteolytic activity in their growth medium [Pubmed|10666719]
The protein
Protein family
[wiki|Peptidase M16 family] (according to UniProt)
Structure
[PDB|3HDI] (from B. halodurans, 64% identity) [pubmed|19913481]
[AF|Q04805]
Expression and Regulation
Operons
Biological materials
Mutant
MGNA-A057 (ymxG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/57 NBRP B. subtilis, Japan]
deletion mutant, available in [wiki|van Dijl] lab
BKE16710 ([gene|2AD0F2C0B0957A9E77EF9771D010ED77459B8CC0|mlpA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE16710 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAATTTGTTCCTCCTATTC, downstream forward: _UP4_TAAAAAGGAAAGCCTGCCCC
BKK16710 ([gene|2AD0F2C0B0957A9E77EF9771D010ED77459B8CC0|mlpA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK16710 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAATTTGTTCCTCCTATTC, downstream forward: _UP4_TAAAAAGGAAAGCCTGCCCC
References
Reviews
Original Publications
Labs working on this gene/protein
[wiki|Jan Maarten van Dijl], Groningen, Netherlands
Page visits: 2966
Time of last update: 2024-12-30 19:55:09
Author of last update: Robert.warneke