cotB
168
spore coat protein (outer)
locus
BSU_36050
Molecular weight
42.81 kDa
pI
9.83
function
resistance of the spore
product
spore coat protein (outer)
essential
no
synonyms
cotB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms
This gene is a member of the following regulons
Gene
Coordinates
3,714,739 3,715,881
The protein
Structure
[AF|P07789]
Modification
phosphorylated on serine residues by [protein|D53067098F693669F61E5CCF6C06664580C40C79|cotH] [Pubmed|27185916]
maturation of CotB requires [protein|49BAFE3E69F1F91AEF4154F55B44639DD3CE4A71|cotG] [Pubmed|26953338]
[wiki|Localization]
outer spore coat, at the middle of the spore as a ring- or spiral-like structure, localization depends on [protein|825AD8D4315A85CD384F9AF6AD894E38E57C88F7|cotE] [Pubmed|22171814,19933362]
Expression and Regulation
Operons
genes
[gene|D53067098F693669F61E5CCF6C06664580C40C79|cotH]-[gene|2A0B2CA7C982C03C1AFBDB3540A918EE937B06CB|cotB]-[gene|61004D2C1EDA3CD84514FD6D468BF594575616F4|ywrJ]
description
[Pubmed|22383849]
regulation
expressed late during sporulation in the mother cell ([wiki|SigE], [protein|search|SigK], [protein|search|GerE], [wiki|SpoIIID]) [Pubmed|26577401,15699190,8755863,15470121]
regulatory mechanism
[protein|0D7F5504590512E1598B94DC1734BF8FF67ED994|gerR]: activation, [Pubmed|20435725], in [regulon|protein:0D7F5504590512E1598B94DC1734BF8FF67ED994|gerR regulon]
[protein|19228BAD44E6DA3DE908DC390FDF628C18D94E65|gerE]: repression, [Pubmed|15470121], in [regulon|protein:19228BAD44E6DA3DE908DC390FDF628C18D94E65|gerE regulon]
[protein|90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|spoIIID]: activation, [Pubmed|26577401], in [regulon|protein:90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|spoIIID regulon]
sigma factors
[protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK]: sigma factor, [Pubmed|15699190,8755863,1691789,12480901], in [regulon|protein:24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK regulon]
[protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]: sigma factor, [Pubmed|15383836], in [regulon|protein:3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE regulon]
genes
[gene|2A0B2CA7C982C03C1AFBDB3540A918EE937B06CB|cotB]-[gene|61004D2C1EDA3CD84514FD6D468BF594575616F4|ywrJ]
description
[Pubmed|22383849]
regulation
expressed late during sporulation in the mother cell ([protein|search|SigE], [protein|search|SigK], [protein|search|GerE], [protein|search|GerR]) [Pubmed|15699190,1691789,15383836,20435725]
Biological materials
Mutant
1S102 ( ''cotB''::''cat''), [Pubmed|2821284], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S102&Search=1S102 BGSC]
BKE36050 ([gene|2A0B2CA7C982C03C1AFBDB3540A918EE937B06CB|cotB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE36050 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCAAATTCCTCCTAGTC, downstream forward: _UP4_TAATAGATAATGGAGGAGCA
BKK36050 ([gene|2A0B2CA7C982C03C1AFBDB3540A918EE937B06CB|cotB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK36050 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCAAATTCCTCCTAGTC, downstream forward: _UP4_TAATAGATAATGGAGGAGCA
References
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Time of last update: 2024-10-10 22:45:33
Author of last update: Jstuelk