spo0B

spo0B
168

[category|SW.4.2|Sporulation] initiation phosphotransferase of the [wiki|phosphorelay]

locus
BSU_27930
Molecular weight
22.40 kDa
pI
4.96
Protein length
Gene length
function
initiation of [wiki|sporulation]
product
[wiki|sporulation ]initiation phosphotransferase
essential
no
synonyms
spo0B, spo0D

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG5802 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,853,981  2,854,559
Phenotypes of a mutant
Arrest of [wiki|sporulation ]at stage 0 (initiation) [pubmed|4633157]
The protein
Structure
[PDB|1F51] (complex with [protein|9896B99346B0D3F6D57F57377DB253B46135A37A|spo0F])
[PDB|1IXM]
[AF|P06535]
Expression and Regulation
Operons
genes
[gene|29D91115BB3AC03538D618E54A5A57F92777EFF6|spo0B]-[gene|84E7D672DB40B114DC4D96A4D8834958B47401A7|obg]-[gene|A4B7CF7A1C704C750AFAD97A43AF975260935083|thrR]-[gene|D4CCF6727AAC048792E59717E588C36EB617249D|pheA]
description
[Pubmed|22383849]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|2537815], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
expression is repressed by binding of [wiki|RpoE] to the A-rich sequence in the -35 region of the promoter [Pubmed|27679485]
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[gene|29D91115BB3AC03538D618E54A5A57F92777EFF6|spo0B]→[gene|D4CCF6727AAC048792E59717E588C36EB617249D|pheA]

2024-10-07 09:22:28

ghost

89

22e8673d70be078a28f38f2ef0353054aac7a361

EFF1EF2402AB3F0071535ACBC9F9FB0A68987C02

Biological materials
Mutant
[http://www.ncbi.nlm.nih.gov/nuccore/254763670 spo0B12], point mutation 85C>T (=R29W), available in [http://bgsc.org/ BGSC] 1S54
[http://www.ncbi.nlm.nih.gov/nuccore/254763672 spo0B136], amber mutation 103A>T (=K35X), available in [http://bgsc.org/ BGSC] 1S16
[http://www.ncbi.nlm.nih.gov/nuccore/254763674 spo0B580ts], point mutation 193G>A (=E65K), available in [http://bgsc.org/ BGSC] 1S90
[http://www.ncbi.nlm.nih.gov/nuccore/254763676 spo0B581ts], point mutation 461G>A (=G154D), available in [http://bgsc.org/ BGSC] 1S91
BKE27930 ([gene|29D91115BB3AC03538D618E54A5A57F92777EFF6|spo0B]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE27930 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTTTCGCACTCCCAATCA,  downstream forward: _UP4_TAGCGGAGTTTTTAACGGTT
BKK27930 ([gene|29D91115BB3AC03538D618E54A5A57F92777EFF6|spo0B]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK27930 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTTTCGCACTCCCAATCA,  downstream forward: _UP4_TAGCGGAGTTTTTAACGGTT
References
Reviews
28886686,35638784
Original Publications
20413551,12730135,2437099,9141138,3918016,9299348,16788205,12067336,9726997,2118512,10997904,1846779,9477965,2537815,23490197,27501195,30212463

29D91115BB3AC03538D618E54A5A57F92777EFF6

Page visits: 3636

Time of last update: 2024-10-07 08:09:38

Author of last update: Jstuelk