uptA
168
undecaprenyl phosphate transporter A, regeneration of the cytoplasmic pool of undecaprenyl phosphate for peptidoglycan and teichoic acid biosynthesis
locus
BSU_18190
Molecular weight
21.78 kDa
pI
9.77
function
recycling of undecaprenyl phosphate for peptidoglycan and teichoic acid biosynthesis
product
undecaprenyl phosphate transporter A
essential
no
synonyms
yngC
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0586 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,947,668 1,948,264
The protein
Catalyzed reaction/ biological activity
flips surface-exposed undecaprenyl phosphate to the cytoplasmic side [pubmed|36450357]
Protein family
dedA family (with [protein|B2C089DCE51CA0CB11947FCD6F4EFAFF66269829|petA] and [protein|96CE303E9F757FBEBDEA5ADC8481697E2CD1361A|ykoX], according to UniProt) [pubmed|36450357,23086209]
Structure
[AF|O31823]
Paralogous protein(s)
[protein|B2C089DCE51CA0CB11947FCD6F4EFAFF66269829|petA]
[protein|96CE303E9F757FBEBDEA5ADC8481697E2CD1361A|ykoX], (43%)
[wiki|Localization]
cell membrane [pubmed|36450357]
Expression and Regulation
Operons
genes
[gene|CBCBF948979D9D63CBA86A9ED865E43B1F85A0AD|yngA]-[gene|69C5D9EF7ED43BCAB7A9D6148EDD323CE72F8E3D|yngB]-[gene|289828D37CF5422908316ED2EF1AEAE76F84161D|uptA]
description
[Pubmed|20512483]
regulation
expression during spore [wiki|germination] is strongly reduced under conditions of osmotic stress [Pubmed|27766092]
expressed under anaerobic conditions ([protein|706983E6942E883D3A9D45693E7B4015AEABE60B|yclJ]) [pubmed|33556370]
regulatory mechanism
[protein|706983E6942E883D3A9D45693E7B4015AEABE60B|yclJ]: activation, [Pubmed|20512483], in [regulon|protein:706983E6942E883D3A9D45693E7B4015AEABE60B|yclJ regulon]
genes
[gene|289828D37CF5422908316ED2EF1AEAE76F84161D|uptA]
description
[Pubmed|18179421]
sigma factors
[protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM]: sigma factor, [pubmed|18179421], in [regulon|protein:081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM regulon]
Biological materials
Mutant
MGNA-B397 (yngC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1396 NBRP B. subtilis, Japan]
BKE18190 ([gene|289828D37CF5422908316ED2EF1AEAE76F84161D|uptA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE18190 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACATTCTTCACAACCTGTC, downstream forward: _UP4_TAGCTAGCGGATATGCATAG
BKK18190 ([gene|289828D37CF5422908316ED2EF1AEAE76F84161D|uptA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK18190 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACATTCTTCACAACCTGTC, downstream forward: _UP4_TAGCTAGCGGATATGCATAG
Reviews
References
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Time of last update: 2024-12-21 14:45:13
Author of last update: Jstuelk