tpx
168
probable thiol peroxidase
locus
BSU_29490
Molecular weight
18.07 kDa
pI
4.7
function
unknown
product
unknown
essential
no
synonyms
tpx, ytgI
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2077 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,017,696 3,018,199
The protein
Catalyzed reaction/ biological activity
[protein]-dithiol + hydroperoxide --> [protein]-disulfide + alcohol + H2O (according to UniProt)
Protein family
[wiki|peroxiredoxin family] (according to UniProt)
[wiki|Domains]
[wiki|Thioredoxin domain] (aa 18-167) (according to UniProt)
Structure
[PDB|2JSZ]
[AF|P80864]
Expression and Regulation
Operons
genes
[gene|2501228D435B151F151A3C0EF10DE99A8395977F|tpx]-[gene|2C83EECFA809F34ADCA6445CF2E6BAC730D523DB|ytxK]
description
[Pubmed|22383849]
regulatory mechanism
[protein|2C6386E9A63F410558D168798D077DF91590F454|spx]: activation, [pubmed|12642660,19575568], in [regulon|protein:2C6386E9A63F410558D168798D077DF91590F454|spx regulon]
genes
[gene|2501228D435B151F151A3C0EF10DE99A8395977F|tpx]
description
[Pubmed|9387221]
regulatory mechanism
[protein|2C6386E9A63F410558D168798D077DF91590F454|spx]: activation, [Pubmed|12642660,19575568], in [regulon|protein:2C6386E9A63F410558D168798D077DF91590F454|spx regulon]
Biological materials
Mutant
MGNA-A113 (ytgI::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/113 NBRP B. subtilis, Japan]
BKE29490 ([gene|2501228D435B151F151A3C0EF10DE99A8395977F|tpx]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE29490 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTATAATTCCTCCCTTTT, downstream forward: _UP4_TAAGCAGGGAAAAAAGCTCC
BKK29490 ([gene|2501228D435B151F151A3C0EF10DE99A8395977F|tpx]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK29490 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTATAATTCCTCCCTTTT, downstream forward: _UP4_TAAGCAGGGAAAAAAGCTCC
References
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Time of last update: 2024-12-20 11:10:52
Author of last update: Jstuelk