xylA
168
xylose isomerase
locus
BSU_17600
Molecular weight
50.09 kDa
pI
5.64
function
utilization of xylan and xylose
product
xylose isomerase
essential
no
ec
5.3.1.5
synonyms
xylA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2115 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,891,908 1,893,245
The protein
Catalyzed reaction/ biological activity
D-xylose --> D-xylulose
Protein family
xylose isomerase family (according to Swiss-Prot)
Structure
[PDB|1A0D] (Geobacillus stearothermophilus)
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|24829427B4518FE67038F194B54D4AAFAC64EF19|xylA]-[gene|F417A5B46CC7FC69DC8606A46D1AD5E41FA35B13|xylB]
description
[Pubmed|1921970]
regulation
carbon catabolite repression ([protein|search|CcpA]) [Pubmed|8132469]
regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|8132469], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
[protein|AF4395D134485290F4AA307B48494FED39E52CD7|xylR]: repression, [Pubmed|2454911], in [regulon|protein:AF4395D134485290F4AA307B48494FED39E52CD7|xylR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|2454911], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
GP1151 (del aphA3) available in [wiki|Jörg Stülke]'s lab
1A719 (no resistance), [Pubmed|1719948], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A719&Search=1A719 BGSC]
BKE17600 ([gene|24829427B4518FE67038F194B54D4AAFAC64EF19|xylA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE17600 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTGATTTCCCCCTTAAA, downstream forward: _UP4_TAACAGGATAAGCTCCAGAT
BKK17600 ([gene|24829427B4518FE67038F194B54D4AAFAC64EF19|xylA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK17600 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTGATTTCCCCCTTAAA, downstream forward: _UP4_TAACAGGATAAGCTCCAGAT
References
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Time of last update: 2024-11-09 01:57:06
Author of last update: Christoph.elfmann