cydD
168
ABC transporter required for expression of cytochrome bd ([metabolite|ATP]-binding protein)
locus
BSU_38730
Molecular weight
64.34 kDa
pI
6.22
function
required for expression of cytochrome bd
product
ABC transporter ([metabolite|ATP]-binding protein)
essential
no
synonyms
cydD, yxkN
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG4987 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,973,364 3,975,091
The protein
Protein family
[wiki|ABC transporter superfamily] (according to UniProt)
[wiki|Domains]
has both a membrane-spanning and an ATP-binding domain [Pubmed|10092453]
[wiki|ABC transmembrane type-1 domain] (aa 18-303) (according to UniProt)
[wiki|ABC transporter domain] (aa 337-570) (according to UniProt)
Structure
[PDB|2HYD] (from Staphylococcus aureus, 28% identity) [pubmed|16943773]
[AF|P94367]
[wiki|Localization]
cell membrane [Pubmed|10092453]
Expression and Regulation
Operons
genes
[gene|C0459C0D45E31561D281E016D86CD80DCAF13357|cydA]-[gene|E66EAB3C172ED8D1D26C675A7338B8153FB66987|cydB]-[gene|A65576E0261F1950A0DAD72B2432D97AB3EB2AA5|cydC]-[gene|244BF9E397FDB0691FFAA8C9D419B0AE417CACE1|cydD]
description
[Pubmed|16207915]
regulation
expressed under anaerobic conditions ([protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]) [Pubmed|17322317]
expression
expression is heterogeneous [pubmed|35171018]
regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
[protein|B5EF521437323EF43F08E5EFDB5C798616CA499A|rex]: repression, [Pubmed|15231791], in [regulon|protein:B5EF521437323EF43F08E5EFDB5C798616CA499A|rex regulon]
[protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]: activation, [Pubmed|17322317], in [regulon|protein:1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD regulon]
sigma factors
[protein|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF]: sigma factor, [PubMed|16497325], in [regulon|protein:CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF regulon]
genes
[gene|244BF9E397FDB0691FFAA8C9D419B0AE417CACE1|cydD]
description
[pubmed|16497325]
regulation
expressed under anaerobic conditions ([protein|search|ResD]) [Pubmed|17322317]
Biological materials
Mutant
MGNA-B748 (cydD::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1747 NBRP B. subtilis, Japan]
BKE38730 ([gene|244BF9E397FDB0691FFAA8C9D419B0AE417CACE1|cydD]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE38730 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CGGCAAAATCCATTCTTCTT, downstream forward: _UP4_TAAAAGACAGCCCTAAAAGG
BKK38730 ([gene|244BF9E397FDB0691FFAA8C9D419B0AE417CACE1|cydD]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK38730 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CGGCAAAATCCATTCTTCTT, downstream forward: _UP4_TAAAAGACAGCCCTAAAAGG
References
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Time of last update: 2024-12-21 02:18:04
Author of last update: Jstuelk