lmrB
168
lincomycin-resistance protein (multidrug resistance pump)
locus
BSU_02670
Molecular weight
51.54 kDa
pI
9.7
function
resistance to lincomycin
product
lincomycin-resistance protein
essential
no
synonyms
lmrB, yccA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2814 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
288,653 290,092
The protein
Protein family
[wiki|major facilitator superfamily] (according to UniProt)
[wiki|EmrB family] (according to UniProt)
Structure
[AF|O35018]
Paralogous protein(s)
[protein|93159DC7D5C42CFA54F66F232D73F38957243AB7|yhcA], [protein|188742B9A0C95344D32A4C23B9C971660572CF7D|ycnB]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|52D560AA02F0849CB24460A496021560063B2E12|lmrA]-[gene|23483430AE0381406EF2349A18CFAE1F14F9B180|lmrB]
description
[Pubmed|15317768]
regulation
induced by flavonoids such as quercetin ([protein|search|LmrA])[Pubmed|17483215]
regulatory mechanism
[protein|52D560AA02F0849CB24460A496021560063B2E12|lmrA]: repression, [Pubmed|15317768], in [regulon|protein:52D560AA02F0849CB24460A496021560063B2E12|lmrA regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|12499232], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
the mRNA is substantially stabilized upon depletion of [gene|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [PubMed|21815947]
Biological materials
Mutant
GP1701 (''[gene|23483430AE0381406EF2349A18CFAE1F14F9B180|lmrB]''::''aphA3''), available in [wiki|Jörg Stülke]'s lab
GP1703 (''[gene|23483430AE0381406EF2349A18CFAE1F14F9B180|lmrB]''::''aphA3'' ''[gene|188742B9A0C95344D32A4C23B9C971660572CF7D|ycnB]''::''spc''), available in [wiki|Jörg Stülke]'s lab
BKE02670 ([gene|23483430AE0381406EF2349A18CFAE1F14F9B180|lmrB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE02670 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTCCCCTCTCTATCAAC, downstream forward: _UP4_TAATATGAAAAGCCCCTGAC
BKK02670 ([gene|23483430AE0381406EF2349A18CFAE1F14F9B180|lmrB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK02670 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTCCCCTCTCTATCAAC, downstream forward: _UP4_TAATATGAAAAGCCCCTGAC
References
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Time of last update: 2024-12-29 06:15:22
Author of last update: Melvin.boenninger