menB

menB
168

naphthoate synthase

locus
BSU_30800
Molecular weight
29.75 kDa
pI
5.34
Protein length
271 aaSequenceBlast
Gene length
816 bpSequenceBlast
function
biosynthesis of menaquinone
product
naphthoate synthase
essential
yes
ec
4.1.3.36
synonyms
menB
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0447 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,148,901  3,149,716
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
2-succinylbenzoyl-CoA + H+ --> 1,4-dihydroxy-2-naphthoyl-CoA + H2O (according to UniProt)
Protein family
[wiki|enoyl-CoA hydratase/isomerase family] (according to UniProt)
Structure
[PDB|1RJM] (from ''Mycobacterium tuberculosis'', 48% identity, 61% similarity)
[AF|P23966]
Modification
phosphorylated on Arg-78 and Arg-269 [Pubmed|31221751,22517742]
Expression and Regulation
Operons
genes
[gene|224584953B0BC1AF666CD69372B2D53AC56F6752|menB]-[gene|16412BAB04BBF9FD1C3653328923687874C81868|menE]-[gene|9B2F45BC37D4F356B366447A33DC95639EF484EE|menC]
description
[Pubmed|9387221,1629163]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8550504], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
A [protein|search|ncRNA] is predicted between '[protein|search|mntA]' and '[protein|search|menC]' [PubMed|20525796]
Open in new tab

[gene|224584953B0BC1AF666CD69372B2D53AC56F6752|menB]→[gene|9B2F45BC37D4F356B366447A33DC95639EF484EE|menC]

2024-11-01 22:20:45

ghost

88

c8390ec183bfac05f12ebb94a80cf07cf1992fec

43D6A4FCF35A0BD074DE7BBC94193C874185009D

genes
[gene|8EFE4D2B07E54A0EE7D6821C9FEBFC7DC22FDE03|menF]-[gene|E3283812B7EB374EAC8722ECCE28432DE24B7B4C|menD]-[gene|74659B6794496912E139B3CF9EFF787B63729A3F|ytxM]-[gene|224584953B0BC1AF666CD69372B2D53AC56F6752|menB]-[gene|16412BAB04BBF9FD1C3653328923687874C81868|menE]-[gene|9B2F45BC37D4F356B366447A33DC95639EF484EE|menC]
description
[Pubmed|9387221,1629163,8550504]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8550504], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
A [protein|search|ncRNA] is predicted between '[protein|search|mntA]' and '[protein|search|menC]' [PubMed|20525796]
Open in new tab

[gene|8EFE4D2B07E54A0EE7D6821C9FEBFC7DC22FDE03|menF]→[gene|9B2F45BC37D4F356B366447A33DC95639EF484EE|menC]

2024-12-16 22:49:47

ghost

87

a92ddbfdf5b67e100c673490a9f20821b9a45d89

AF4C2B1155E6061073411DDF2040DB62495353C0

References
9387221,1629163,8550504,22517742,31221751

224584953B0BC1AF666CD69372B2D53AC56F6752

Page visits: 3974

Time of last update: 2024-12-21 05:10:19

Author of last update: Melvin.boenninger