clsA
168
cardiolipin synthase, major enzyme
locus
BSU_36590
Molecular weight
55.70 kDa
pI
9.55
function
biosynthesis of phospholipids
product
cardiolipin synthase, major enzyme
essential
no
synonyms
clsA, ywnE
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1502 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,762,664 3,764,112
Phenotypes of a mutant
increased conjugation of ICEBs1 [Pubmed|26833415]
The protein
Catalyzed reaction/ biological activity
2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) --> cardiolipin + glycerol (according to UniProt)
Protein family
phospholipase D family (with [protein|B63AAF0D3277FD776944A09D2546F3E48C8716AD|ywjE] and [protein|07752EC6940F43DEBD1E9313A2A195E35EDB9F69|ywiE], according to UniProt)
[wiki|Domains]
2 PLD phosphodiesterase domains (aa 217-244, aa 395-422) (according to UniProt)
Structure
[AF|P71040]
Paralogous protein(s)
[protein|B63AAF0D3277FD776944A09D2546F3E48C8716AD|ywjE], [protein|07752EC6940F43DEBD1E9313A2A195E35EDB9F69|ywiE]
[wiki|Localization]
cell membrane at the septum, this localization depends on two C-terminal helices [Pubmed|26708983,15743965]
Expression and Regulation
Operons
genes
[gene|2079B210322F26EEC3CCF55611622FADDB1D1BC7|clsA]
description
[Pubmed|22383849]
Biological materials
Mutant
BKE36590 ([gene|2079B210322F26EEC3CCF55611622FADDB1D1BC7|clsA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE36590 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTTTGTAACCCCGCTCAT, downstream forward: _UP4_TAAGATGCGTAAACCCCCGG
BKK36590 ([gene|2079B210322F26EEC3CCF55611622FADDB1D1BC7|clsA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK36590 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTTTGTAACCCCGCTCAT, downstream forward: _UP4_TAAGATGCGTAAACCCCCGG
References
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Time of last update: 2024-12-30 21:55:57
Author of last update: Melvin.boenninger