aimP
168
peptide, part of the arbitrium peptide-based communication system, processed [protein|20735BFECA52826F0F4D55843EEE7798F414993C|aimP] peptide inactivates [protein|CAE7D8E45DA7CDE99D3EA114DF7E368A0A126389|aimR]
locus
BSU_20850
Molecular weight
4.08 kDa
pI
6.26
function
control of [protein|CAE7D8E45DA7CDE99D3EA114DF7E368A0A126389|aimR] activity
product
arbitrium peptide
essential
no
ec
null
synonyms
aimP, AimP, yopL
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms
This gene is a member of the following regulons
Gene
Coordinates
2,208,855 2,208,980
Phenotypes of a mutant
increased prophage production [pubmed|34562384]
sharper plaque morphology (similar to [gene|01BE35FB190DDC77BE19C013A8E0D980B132CBE1|yopN] mutant) [pubmed|34562384]
The protein
Catalyzed reaction/ biological activity
Proteolytically cleaved in extracellular space to yield hexapeptide (GMPRGA) regulator. Hexapeptide re-enters cells and binds to [protein|CAE7D8E45DA7CDE99D3EA114DF7E368A0A126389|aimR] to promote SPbeta lysogeny. ([Pubmed|31149347])
Structure
Hexapeptide bound to [protein|CAE7D8E45DA7CDE99D3EA114DF7E368A0A126389|aimR]: [PDB|5Y24] ([Pubmed|30224798]), [PDB|5ZW6] ([Pubmed|30323253]), [PDB|6IM4] ([Pubmed|30421358]), [PDB|6HP5] ([Pubmed|30745087]), [PDB|6JG9] ([Pubmed|31149347])
[AF|O31926]
Expression and Regulation
Operons
genes
[gene|CAE7D8E45DA7CDE99D3EA114DF7E368A0A126389|aimR]-[gene|20735BFECA52826F0F4D55843EEE7798F414993C|aimP]
description
[pubmed|22383849]
expression
repressed by [protein|7F82DED7C941BC501B6F810BF6541780AB87EDDD|mrpR]
regulatory mechanism
[protein|7F82DED7C941BC501B6F810BF6541780AB87EDDD|mrpR]: repression, in [regulon|protein:7F82DED7C941BC501B6F810BF6541780AB87EDDD|mrpR regulon]
genes
[gene|20735BFECA52826F0F4D55843EEE7798F414993C|aimP]
description
[pubmed|22383849]
regulation
expressed during the lytic cycle [pubmed|34562384]
regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: transcription repression [Pubmed|12850135], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
additional information
produce as 43 aa pro-peptide, secreted to the medium, and processed to the mature 6 aa AimX peptide that can be taken up by the cells again [pubmed|34562384]
Biological materials
Mutant
BKE20850 ([gene|20735BFECA52826F0F4D55843EEE7798F414993C|aimP]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE20850 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGTCTCACCTCCTTTAA, downstream forward: _UP4_TAAAATCCATTGACACATAA
BKK20850 ([gene|20735BFECA52826F0F4D55843EEE7798F414993C|aimP]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK20850 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGTCTCACCTCCTTTAA, downstream forward: _UP4_TAAAATCCATTGACACATAA
References
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Time of last update: 2025-03-08 03:52:39
Author of last update: Jstuelk