tcyA
168
cystine and diaminopimelate [wiki|ABC transporter] (binding protein)
locus
BSU_03610
Molecular weight
29.32 kDa
pI
9.12
function
cystine uptake
product
cystine and diaminopimelate [wiki|ABC transporter] (binding protein)
essential
no
synonyms
tcyA, yckK
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0834 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
410,656 411,462
The protein
Catalyzed reaction/ biological activity
uptake of cystine and diaminopimelate [pubmed|29995990]
Protein family
[wiki|bacterial solute-binding protein 3 family] (according to UniProt)
Structure
[PDB|2YLN] (from Neisseria gonorrhoeae, 54% identity) [pubmed|22138345]
[AF|P42199]
Paralogous protein(s)
[protein|7050A2CC4BA2183C3CD22A246846CBCE43D73ABC|yckB]
[wiki|Localization]
attached to the membrane via [protein|9400DF25487461E3738DDDC72BDDB1589281409D|tcyB] [Pubmed|10092453]
Expression and Regulation
Operons
genes
[gene|2056F8EEDF9D3027CFD808E8D0C5DF544DBDD3F3|tcyA]-[gene|9400DF25487461E3738DDDC72BDDB1589281409D|tcyB]-[gene|B453986691E1231A1C565D469A2A60EBFF2F6BD3|tcyC]
description
[Pubmed|22383849,15262924]
regulation
strongly repressed in response to glucose starvation in M9 medium [Pubmed|23033921]
Biological materials
Mutant
GP4658 (trpC2 Δ[gene|2056F8EEDF9D3027CFD808E8D0C5DF544DBDD3F3|tcyA]::neo), available in [wiki|Jörg Stülke]'s lab
GP4667 (trpC2 Δ[gene|2056F8EEDF9D3027CFD808E8D0C5DF544DBDD3F3|tcyA]::lox72), available in [wiki|Jörg Stülke]'s lab
BKE03610 ([gene|2056F8EEDF9D3027CFD808E8D0C5DF544DBDD3F3|tcyA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE03610 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTTATTCCCCACTTTTC, downstream forward: _UP4_GAAGATGTTTCTAAATAATC
BKK03610 ([gene|2056F8EEDF9D3027CFD808E8D0C5DF544DBDD3F3|tcyA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK03610 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTTATTCCCCACTTTTC, downstream forward: _UP4_GAAGATGTTTCTAAATAATC
References
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Time of last update: 2024-10-12 04:03:14
Author of last update: Robert.warneke