nrdI
168
flavodoxin, ribonucleoside-diphosphate reductase
locus
BSU_17370
Molecular weight
14.46 kDa
pI
8.58
function
synthesis of deoxyribonucleoside triphosphates
product
ribonucleoside-diphosphate reductase
essential
yes
synonyms
nrdI, ymaA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1780 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,868,617 1,869,009
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
Provides oxidant (O2-) for assembly of dimanganic-tyrosyl radical (MnIII2-Y) cofactor in [protein|CD2D14FE9C10544E7C350167EBDBD941B898051D|nrdF]. [Pubmed|23402532]
Protein family
nrdI family (with [protein|47098DA18DBD3FEF9E33D21677B6D94D5B0ACB2B|yosM], according to UniProt)
[wiki|Cofactors]
FMN [Pubmed|21561096]
Structure
[PDB|1RLJ]
[AF|P50618]
Paralogous protein(s)
[protein|47098DA18DBD3FEF9E33D21677B6D94D5B0ACB2B|yosM]
Expression and Regulation
Operons
genes
[gene|1EA0595C74359A36B9161CFD531CA894C5E66E25|nrdI]-[gene|3B68CE8E9A35997B45E437A316996D585E43B76B|nrdE]-[gene|CD2D14FE9C10544E7C350167EBDBD941B898051D|nrdF]-[gene|8C2A08A8395B72CCC9D03A8154602B8F3B77A1AA|ymaB]
description
[Pubmed|16885274]
regulation
expressed under anaerobic conditions ([protein|search|ResD]) [Pubmed|16885274]
regulatory mechanism
[protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]: activation, [Pubmed|16885274], in [regulon|protein:1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD regulon]
[protein|FD4E988BB73F6476CCEA4C521F343D6F8CBA457F|nrdR]: repression, (predicted) [Pubmed|15949864], in [regulon|protein:FD4E988BB73F6476CCEA4C521F343D6F8CBA457F|nrdR regulon]
[protein|00BCAAE16576DC5426A652580C69A570FC7A1C2C|perR]: transcription repression, [Pubmed|27920297], in [regulon|protein:00BCAAE16576DC5426A652580C69A570FC7A1C2C|perR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|16885274], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
A [protein|search|ncRNA] is predicted between '[protein|search|ymzA]' and '[protein|search|nrdI]' [PubMed|20525796]
genes
[gene|93FA602438546FD6201FAB5BD19DB5DEB5965E48|ymzA]-[gene|1EA0595C74359A36B9161CFD531CA894C5E66E25|nrdI]-[gene|3B68CE8E9A35997B45E437A316996D585E43B76B|nrdE]-[gene|CD2D14FE9C10544E7C350167EBDBD941B898051D|nrdF]-[gene|8C2A08A8395B72CCC9D03A8154602B8F3B77A1AA|ymaB]
description
[Pubmed|22383849]
References
Reviews
Original Publications
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Time of last update: 2024-12-20 10:28:38
Author of last update: Melvin.boenninger