yugJ
168
NADPH-dependent furan aldehyde reductase
locus
BSU_31370
Molecular weight
42.57 kDa
pI
5.22
function
detoxification of furan aldehydes
product
furan aldehyde reductase
essential
no
synonyms
yugJ
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1979 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,223,471 3,224,634
The protein
Protein family
iron-containing alcohol dehydrogenase family (with [protein|B90D4E798145F2AF3421DDC5AB6CD578E2E17900|gbsB] and [protein|D81610C7CA2A92FCB1195591ACB613E7C1288F6B|yugK], according to UniProt)
[wiki|Cofactors]
NADP [pubmed|35163804]
Ni2+ [pubmed|35163804]
Structure
[PDB|1VLJ] (from Thermotoga maritima, 44% identity)
[AF|O05239]
Paralogous protein(s)
[protein|D81610C7CA2A92FCB1195591ACB613E7C1288F6B|yugK]
Expression and Regulation
Operons
genes
[gene|1E951C2B640966643D5F081159522CD1C51942C8|yugJ]
description
[Pubmed|9274030]
regulatory mechanism
[protein|2C6386E9A63F410558D168798D077DF91590F454|spx]: activation, [Pubmed|14597697,19575568], in [regulon|protein:2C6386E9A63F410558D168798D077DF91590F454|spx regulon]
Biological materials
Mutant
MGNA-B549 (yugJ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1548 NBRP B. subtilis, Japan]
BKE31370 ([gene|1E951C2B640966643D5F081159522CD1C51942C8|yugJ]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE31370 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGACATCTCCTCCTTAGA, downstream forward: _UP4_TAAAAAAAGGGGAAATAGCC
BKK31370 ([gene|1E951C2B640966643D5F081159522CD1C51942C8|yugJ]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK31370 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGACATCTCCTCCTTAGA, downstream forward: _UP4_TAAAAAAAGGGGAAATAGCC
References
Reviews
Original Publications
The corresponding protein in ''E. coli
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Time of last update: 2024-12-30 05:35:28
Author of last update: Jstuelk