resD
168
two-component response regulator ([wiki|OmpR family]), regulation of aerobic and anaerobic respiration, activates expression of target genes in response to oxygen limitation
locus
BSU_23120
Molecular weight
27.34 kDa
pI
5.63
function
regulation of aerobic and anaerobic respiration
product
two-component response regulator ([wiki|OmpR family])
essential
no
synonyms
resD, ypxD
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0745 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,417,181 2,417,903
Phenotypes of a mutant
a ''resD'' point mutation has been isolated upon selction at low pressure [Pubmed|26296725]
The protein
Protein family
[wiki|OmpR family] of two-component response regulators
[wiki|Domains]
[wiki|Response regulatory domain] (aa 8-121) (according to UniProt)
Structure
[PDB|2OQR] (RegX3 from Mycobacterium tuberculosis, 37% identity) [pubmed|17942407]
[AF|P35163]
Modification
phosphorylated by [protein|EA6790EF30D3DDB9670FE52DFD2C5083AB6A48E1|resE] on an Asp residue
Effectors of protein activity
phosphorylation likely affects DNA-binding activity
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|5CD1E266B0EC82546A2AF19A05490DD4D04F812C|rluB]-[gene|F7D869F77E2275110737EF658C58FA1BF742D73F|resA]-[gene|495721E4B8BF6FEC01E62E86339560F90776EED1|resB]-[gene|97FE84CF968596AC39D19EE2E43DA625147FD702|resC]-[gene|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]-[gene|EA6790EF30D3DDB9670FE52DFD2C5083AB6A48E1|resE]
description
[Pubmed|22383849]
genes
[gene|F7D869F77E2275110737EF658C58FA1BF742D73F|resA]-[gene|495721E4B8BF6FEC01E62E86339560F90776EED1|resB]-[gene|97FE84CF968596AC39D19EE2E43DA625147FD702|resC]-[gene|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]-[gene|EA6790EF30D3DDB9670FE52DFD2C5083AB6A48E1|resE]
description
[Pubmed|8631715]
regulation
expressed under anaerobic conditions ([protein|search|ResD]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8631715,11222591 PubMed]
regulatory mechanism
[protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]: activation, [PubMed|8631715,11222591], in [regulon|protein:1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD regulon]
[protein|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|phoP]: activation, [Pubmed|9988472], in [regulon|protein:638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|phoP regulon]
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|16825793], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8631715], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
genes
[gene|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]-[gene|EA6790EF30D3DDB9670FE52DFD2C5083AB6A48E1|resE]
description
[Pubmed|8631715]
regulation
expressed under anaerobic conditions ([protein|search|ResD]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8631715,11222591 PubMed]
Biological materials
Mutant
BKE23120 ([gene|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE23120 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTTTCCCCCTGCTTTC, downstream forward: _UP4_TATAAATTTGAGGTCGGCGC
BKK23120 ([gene|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK23120 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTTTCCCCCTGCTTTC, downstream forward: _UP4_TATAAATTTGAGGTCGGCGC
labs
[wiki|Marion Hulett], University of Illinois at Chicago, USA [http://www.uic.edu/depts/bios/faculty/hulett/hulettm.shtml Homepage]
References
Reviews
Original Publications
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Time of last update: 2024-12-31 06:36:23
Author of last update: Jstuelk