gntR
168
transcriptional repressor (GntR family) of the [gene|1C566E54F8EF1A17A365FC49DFDA452AC5D0CA64|gntR]-[gene|72404FA6ECD62AEA3EFDB934DFB8DA581875605C|gntK]-[gene|C6810A4ACD51EB8D14E5B30163348058196266A1|gntP]-[gene|7E7187AA2DC172018A63A7B9CE48124F30311639|gntZ] operon
locus
BSU_40050
Molecular weight
28.13 kDa
pI
5.26
function
regulation of gluconate utilization
product
transcriptional repressor of the gluconate operon
essential
no
synonyms
gntR
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1802 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
4,113,417 4,114,148
The protein
Protein family
[wiki|GntR family] of transcription factors
[wiki|Domains]
[wiki|HTH gntR-type domain] (aa 17-83) (according to UniProt)
Structure
[PDB|7U5Q] ([wiki|GntR family] regulator from Brucella melitensis, corresponding to aa 13 ... 167, 26.9% identity)
[AF|P10585]
Effectors of protein activity
[metabolite|gluconate] acts as molecular inducer
Expression and Regulation
Operons
genes
[gene|1C566E54F8EF1A17A365FC49DFDA452AC5D0CA64|gntR]-[gene|72404FA6ECD62AEA3EFDB934DFB8DA581875605C|gntK]-[gene|C6810A4ACD51EB8D14E5B30163348058196266A1|gntP]-[gene|7E7187AA2DC172018A63A7B9CE48124F30311639|gntZ]
description
[pubmed|10746760,3020045]
regulation
induced by gluconate ([protein|search|GntR]) [Pubmed|3020045]
regulatory mechanism
[protein|1C566E54F8EF1A17A365FC49DFDA452AC5D0CA64|gntR]: repression, [Pubmed|3020045], in [regulon|protein:1C566E54F8EF1A17A365FC49DFDA452AC5D0CA64|gntR regulon]
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|10666464], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
[protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]: activation, [Pubmed|20817675], in [regulon|protein:E5110D9C36E8C55AFD1419987B14A53232165F20|abrB regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|3020045], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
BKE40050 ([gene|1C566E54F8EF1A17A365FC49DFDA452AC5D0CA64|gntR]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE40050 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATACACTCACCTTCCTCAC, downstream forward: _UP4_CTGGCAAAAGGAGCTGAATA
BKK40050 ([gene|1C566E54F8EF1A17A365FC49DFDA452AC5D0CA64|gntR]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK40050 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATACACTCACCTTCCTCAC, downstream forward: _UP4_CTGGCAAAAGGAGCTGAATA
References
Reviews
Original Publications
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Time of last update: 2024-12-25 06:15:52
Author of last update: Jstuelk