gmk
168
guanylate kinase (GMP:dATP, dGMP:ATP)
locus
BSU_15680
Molecular weight
23.07 kDa
pI
4.62
function
GTP biosynthesis
product
guanylate kinase (GMP:dATP, dGMP:ATP)
essential
yes
ec
2.7.4.8
synonyms
gmk, yloD
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0194 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,641,949 1,642,563
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
ATP + GMP --> ADP + GDP (according to UniProt)
Protein family
guanylate kinase family (single member, according to UniProt)
[wiki|Domains]
Guanylate kinase-like domain (aa 5-184) (according to UniProt)
Structure
[PDB|1S4Q] (from ''Mycobacterium tuberculosis h37rv'', 39% identity, 60% similarity)
[http://pdb.org/pdb/search/structidSearch.do?structureId=4QRH 4QRH] (from ''Staphylococcus aureus'', complex with pppGpp) [Pubmed|25661490]
[AF|O34328]
Modification
phosphorylated on Arg-134 and/or Arg-149[Pubmed|22517742]
Effectors of protein activity
inhibition of enzymatic activity by (p)ppGpp during the stringent response[Pubmed|22981860]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|A57D2C1536F3E93CD687C28C59FF297355CAB303|yloC]-[gene|6AF1CB8998BE9C71DF4F1201A7F74FF7E75CB799|remA]-[gene|1BC994DE60A7BB35DEDD7154581A396D29AA94A7|gmk]-[gene|921933B6B893083F151AABDEDCBC65F2E55677BE|yloH]
description
[pubmed|22383849]
regulation
expressed during vegetative growth and early during sporulation in the forespore ([protein|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF]) [Pubmed|23396918]
sigma factors
[protein|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF]: sigma factor, [Pubmed|23396918], in [regulon|protein:CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF regulon]
genes
[gene|A57D2C1536F3E93CD687C28C59FF297355CAB303|yloC]-[gene|6AF1CB8998BE9C71DF4F1201A7F74FF7E75CB799|remA]-[gene|1BC994DE60A7BB35DEDD7154581A396D29AA94A7|gmk]-[gene|921933B6B893083F151AABDEDCBC65F2E55677BE|yloH]-[gene|2B67C63442F28F6BCBA3BA6DE4B563C73E8DF16C|coaBC]-[gene|AF5ADDA2A98EC18BB72A81AA0336E639C0D1F430|priA]-[gene|3D41FB608DB70B9482312A1BBCCDBDA7FB713AFA|defA]-[gene|06971E9AAB033E2878914A76645F99E97CE8A90A|fmt]-[gene|1370D8783450D538C71E3DE8EA5B37DFEE073FF0|yloM]-[gene|5DEBD84E5937DB8B7F29C729FAA0076DF86A5451|yloN]
description
[pubmed|22383849]
genes
[gene|7821A09DADC6EAF589A882F05CC34BE900E06F2A|yloB]-[gene|A57D2C1536F3E93CD687C28C59FF297355CAB303|yloC]-[gene|6AF1CB8998BE9C71DF4F1201A7F74FF7E75CB799|remA]-[gene|1BC994DE60A7BB35DEDD7154581A396D29AA94A7|gmk]-[gene|921933B6B893083F151AABDEDCBC65F2E55677BE|yloH]
description
[pubmed|22383849]
regulation
expressed during sporulation in the mother cell [pubmed|12161109]
References
Reviews
Original Publications
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Time of last update: 2024-12-22 05:24:48
Author of last update: Jstuelk