trxB
168
thioredoxin reductase (NADPH)
locus
BSU_34790
Molecular weight
34.36 kDa
pI
4.99
function
keeps [protein|4E5C84FDC8FE2FEFF47306C91ECAB7F17D3E38E9|thioredoxin] in the reduced state
product
thioredoxin reductase (NADPH)
essential
yes
ec
1.8.1.9
synonyms
trxB, yvcH, trxR
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0492 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,573,207 3,574,157
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
[protein|4E5C84FDC8FE2FEFF47306C91ECAB7F17D3E38E9|Thioredoxin] + NADP+ --> [protein|4E5C84FDC8FE2FEFF47306C91ECAB7F17D3E38E9|thioredoxin] disulfide + NADPH [pubmed|30855939]
Protein family
class-II pyridine nucleotide-disulfide oxidoreductase family (with [protein|8F23B575BC32EA63267C4321DD8E4BD546B11AF1|ahpF], according to UniProt)
[wiki|Cofactors]
FAD [Pubmed|30855939]
Structure
[PDB|4GCM] (from ''S. aureus, 71% identity'')
[AF|P80880]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|1BC439BBCD5FE19D5780519D7E4317C2EFF0D21B|trxB]
description
[pubmed|22383849]
regulation
induced by cell wall stress ([protein|2C6386E9A63F410558D168798D077DF91590F454|spx]) [pubmed|29271514]
regulatory mechanism
[protein|2C6386E9A63F410558D168798D077DF91590F454|spx]: activation, [Pubmed|29271514,12642660], in [regulon|protein:2C6386E9A63F410558D168798D077DF91590F454|spx regulon]
References
Reviews
Original Publications
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Time of last update: 2024-10-08 12:02:07
Author of last update: Melvin.boenninger