ycnI
168
putative copper chaperone
locus
BSU_03940
Molecular weight
21.97 kDa
pI
4.83
function
copper homeostasis
product
copper-binding protein
essential
no
synonyms
ycnI
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG4549 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
446,174 446,788
The protein
Catalyzed reaction/ biological activity
binds a Cu2+ ion [pubmed|34400169]
[wiki|Domains]
DUF1775 domain [pubmed|34400169]
Structure
[PDB|7ME6] apo form [pubmed|34400169]
[PDB|7MEK] Cu bound form [pubmed|34400169]
[PDB|3ESM] (from Nocardia farcinica, corresponds to aa 25 ... 137, 34.5% identity)
[AF|P94431]
[wiki|Localization]
cell membrane [pubmed|30602489]
Expression and Regulation
Operons
genes
[gene|98D807FBB847BF731B5C236557C8F70347279CE0|ycnK]-[gene|D0F553E661A35C69380ACB01D9A96FC6C5088470|ycnJ]-[gene|1B7F59F954A1F20F75F5D4953F84CE58171741DE|ycnI]
description
[Pubmed|22904286,22383849]
regulation
induced by copper limitation ([protein|search|YcnK]) [Pubmed|22904286,19168619]
regulatory mechanism
[protein|98D807FBB847BF731B5C236557C8F70347279CE0|ycnK]: repression, [Pubmed|22904286,19168619], in [regulon|protein:98D807FBB847BF731B5C236557C8F70347279CE0|ycnK regulon]
[protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]: repression, [Pubmed|15101989], in [regulon|protein:E5110D9C36E8C55AFD1419987B14A53232165F20|abrB regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|22904286], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
BKE03940 ([gene|1B7F59F954A1F20F75F5D4953F84CE58171741DE|ycnI]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE03940 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAACGTAAACACTCCTTAAT, downstream forward: _UP4_TAATAAAGAAAGCGATCCAG
BKK03940 ([gene|1B7F59F954A1F20F75F5D4953F84CE58171741DE|ycnI]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK03940 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAACGTAAACACTCCTTAAT, downstream forward: _UP4_TAATAAAGAAAGCGATCCAG
References
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Time of last update: 2024-10-06 15:30:27
Author of last update: Jstuelk